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m-Cresol - ipcs inchem

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OECD SIDS<br />

p-CRESOL<br />

4. ECOTOXICITY ID: 106-44-5<br />

DATE: 24.05.2004<br />

Unsuitable test system. Organisms are of marine origin. Method is not<br />

appropriate for the hazard assessment of chemicals.<br />

07.05.2004 (113)<br />

Type : Aquatic<br />

Species : other bacteria: gentechnologically constructed luminescent bacteria<br />

originating from wastewater treatment plant<br />

Exposure period : 30 minute(s)<br />

Unit : mg/l<br />

EC50 : 21 measured/nominal<br />

Analytical monitoring : No<br />

Method : other: Microtox assay<br />

Year : 1986<br />

GLP : no data<br />

Test substance : other TS: p-cresol, no purity reported<br />

Remark : Inhibition of bioluminescence<br />

Modified microorganisms used which represent the metabolic potentials<br />

present in a wastewater treatment plant and some properties of a marine<br />

organism, but which are not identical to any known species in natural<br />

environments<br />

Test condition : - Wastewater bacteria (Eschericia coli) which were obtained from a<br />

wastewater treatment plant<br />

- Bacteria obtained the luciferase operon of Vibrio fischeri by transfer from<br />

luminescent E. coli<br />

- Incubation at 20 °C<br />

- Result calculated from the difference of the luminescence between<br />

controls and test substance taking into account the light emissions at 0 and<br />

20 °C<br />

Reliability : (3) invalid<br />

Unsuitable test system. Organisms are of marine origin. Method is not<br />

appropriate for the hazard assessment of chemicals.<br />

07.05.2004 (113)<br />

Type : Aquatic<br />

Species : Pseudomonas fluorescens (Bacteria)<br />

Exposure period :<br />

Unit : mg/l<br />

TT : = 30<br />

Analytical monitoring : No<br />

Method :<br />

Year : 1960<br />

GLP : No<br />

Test substance : other TS: p-cresol, no purity reported<br />

Remark : TT = toxicity treshold; determined at 5% effect compared to<br />

control<br />

endpoint: inhibition of glucose metabolism<br />

Reliability : (3) invalid<br />

Experimental details missing<br />

07.05.2004 (111)<br />

Type : Aquatic<br />

Species : other bacteria: Photobacterium (Vibrio) fischeri (marine)<br />

Exposure period : 5 minute(s)<br />

Unit : mg/l<br />

EC10 : = 1.3<br />

Analytical monitoring : No<br />

Method : other: Microtox assay<br />

Year : 1981<br />

GLP : No<br />

242<br />

UNEP PUBLICATIONS

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