m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Value : = 1400 mg/kg bw
Species : rabbit
Strain :
Sex : no data
Number of animals : 1
Vehicle : other: water
Doses :
Method : other: single oral gavage of a 20 % aqueous emulsion, 4 doses, time till
death was recorded
Year : 1944
GLP : no data
Test substance : other TS: purity not mentioned
Remark : 620 and 940 mg/kg: no death; 1400 mg/kg: 8 hrs until death;
2100 mg/kg 90 min. till death
Reliability : (4) not assignable
study reporting suffers from deficiencies
17.12.2002 (118)
Type : other: LD
Value : 640 - 1000 mg/kg bw
Species : dog
Strain :
Sex : no data
Number of animals : 2
Vehicle : no data
Doses :
Method : other: single application by gavage, no further data
Year : 1907
GLP : no data
Test substance : other TS: no data on purity
Remark : 640 mg/kg: transitional aggitation, staggering gait,
sedation, recovery
1000 mg/kg: death within 30 min after application probably
due to aspiration
Reliability : (4) not assignable
study reporting suffers from deficiencies
17.12.2002 (111)
5.1.2 ACUTE INHALATION TOXICITY
124
Type : LC50
Value : > .71 mg/l
Species : rat
Strain :
Sex : male
Number of animals : 6
Vehicle : other: air
Doses :
Exposure time : 1 hour(s)
Method : other: 6 rats exposed to 0.71 mg/l for 1 hr, room temperature, up to 14 d
post exposure observation, gross necropsy
Year : 1969
GLP : no data
Test substance : other TS: m-cresol, M.p.: 11-12 C; B.P.: 202.8 C
Result : Mortality. 0/6; signs of intoxication: none; gross autopsy:
no significant findings
Reliability : (2) valid with restrictions
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