m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
3. ENVIRONMENTAL FATE AND PATHWAYS ID: 106-44-5
DATE: 24.05.2004
Method : Determination of absorption rate across gills
Analytical measurements in inspired and expired water,
calculation of gill uptake efficiency
Result : About 23% of the TS were taken up via the gills (value taken
from a graphics)
Test condition : 1 fish per experiment
Reliability : (3) invalid
Only 1 fish tested, no BCF determined
07.05.2004 (75)
3.8 ADDITIONAL REMARKS
Memo : biodegradation under three different anaerobic (denitrifying, sulfidogenic,
methanogenic) conditions
Method : biodegradation was studied with acclimated and unacclimated sedimet
samples from a freshwater pond
Result : the proposed reaction pathway is: p-Cresol > p-hydroxybenzyl alcohol > p-
hydroxybenzaldehyde > p-hydroxybenzoate for all three conditions. Under
methanogenic conditions, p-hydroxybenzoate reacts to benzoate with
subsequent ring fission. Under denitrifying and sulfidogenic conditions, p-
hydroxybenzoate did not react to benzoate, immediate ring fission is
postulated.
Test substance : other TS: p-cresol, no purity reported (Aldrich, Milwaukee, WI)
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail
12.12.2002 (70)
Memo : biodegradation under anaerobic (sulfate-reducing) conditions
Method : acclimated aquifer slurries (alluvial sand) amended with either Na2MoO4,
bromoethanesulfonic acid, or Na2SO4
HPLC measurements
Result : the proposed reaction pathway is: p-Cresol > p-hydroxybenzyl alcohol > p-
hydroxybenzaldehyde > p-hydroxybenzoate
Test substance : other TS: p-cresol, no purity reported (obtained from Aldrich Chemical Co.)
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail
12.12.2002 (68)
Memo : biodegradation under anaerobic (sulfate-reducing) conditions
Method : Ring-14C-labeled p-cresol incubated with bacteria enriched
from the sulfate-reducing portion of an anoxic aquifer.
Periodical analysis of the enrichment by HPLC.
Result : the proposed reaction pathway is: p-Cresol > p-hydroxybenzyl alcohol > p-
hydroxybenzaldehyde > p-hydroxybenzoic acid. The pathway diverges
after p-hydroxybenzoic acid to form benzoic
acid and phenol.
Test substance : Ring-14C-labeled p-cresol
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally accepted
scientific standards and described in sufficient detail
12.12.2002 (76)
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