m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
NOAEL : 1000 ppm
Method : other: see freetext ME
Year : 1991
GLP : yes
Test substance : other TS: p-cresol, purity > 98%
Method : SIZE OF STUDY GROUP:
5 male and 5 female rat per group
TIME HELD BEFORE STUDY: 13-15 days
METHOD OF ANIMAL DISTRIBUTION:
randomized for each sex on the basis of body weight into groups per sex
DIET: NIH-07 rat ration
ANIMAL ROOM ENVIRONMENT:
temperature: 72° +/-3° F, humidity: 50 % +/-15 %, Fluorescent light: 12
hrs/day, room air changes : 10-12 changes/hr
TYPE AND FREQUENCY OF OBSERVATION:
observed twice daily, body weight taken initially, weekly, and at termination,
feed consumption by cage recorded twice weekly
NECROPSY AND HISTOLOGIC EXAMINATION:
necropsy and tissue collection performed for all animals. A complete
histopathologic examination was conducted on all control animals, all
animals in the highest dose group with at least 60 % survivors at study
termination, and all aninmals in higher dose groups inclusive of early
deaths. The following organs and/or tissues were included in complete
histopathological examinations, as well as any tissue masses, gross
lesions, and associated regional lymph nodes: adrenals, aorta, bone
(sternebrae, femur, or vertebrae, including marrow), brain, bronchi, clitoral
gland, epididymis, oesophagus, heart, kidney, large intestines (caecum,
colon, rectum), liver, lungs, lymph nodes (mesenteric), mammary glands,
nasal cavity and turbinates, oral cavity, ovaries, pancreas, parathyroids,
pharynx, pituirary, preputial gland, prostate, salivary glands, scrotal sac,
seminal vesicles, skin, small intestine (duodenum, ileum, jejunum), spleen,
stomach, testes, thymus, thyroid, tongue, trachea, tunica vaginalis, urinary
bladder, uterus and Zymbal's glands. Target organs and gross lesions
were examined at lower doses until a no-observed chemical effect was
determined. Target organs included the following: nasal epithelium, bone
marrow, uterus, liver, kidney. Organ weights recorded for brain, liver, right
kidney, thymus, heart, and lungs of all animals, and the right testis of all
males.
STATISTICAL METHODS:
nonparametric multiple comparison test of Dunn and Shirley,
Jonckheere's test
Remark :
mean compound consumption (mg/kg bw/day):
males females
0 ppm 0 0
300 ppm 25 25
1000 ppm 87 83
3000 ppm 256 242
10000 ppm 835 769
30000 ppm 2180 2060
Result : There were no deaths.
30000 ppm: Decreased mean final body weights, body weight gains and
feed consumption occurred in both the
top-dose males and females. These animals also showed
clinical signs of toxicity, including hunched posture and
rough hair coat (individual animal data not given).
At study termination, weights (w) were sign. increased:
liver (male, rel. w from 10000 ppm, p