m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
5.1.4 ACUTE TOXICITY, OTHER ROUTES
Type : other
Value : = 110 mg/kg bw
Species : mouse
Strain :
Sex :
Number of animals :
Vehicle :
Doses :
Route of admin. : i.p.
Exposure time :
Method : other
Year :
GLP : no data
Test substance : no data
Remark : p-Cresol, dissolved in 0.9% saline, was administered to
anaesthetized albino Sheffield mice by intraperitoneal
injection. The dose inducing convulsions in 50% of the
mice (CD50) was measured; the endpoint being taken as
myoclonic jerks of limbs and tails.
The intraperitoneal dose inducing convulsions in 50% of a
group of six male mice (CD50) was 1.02 (95% CI 0.68-1.54)
mM/kg bw (110 (95% CI 74-167) mg/kg bw).
22.03.2001 (142)
Type : LC50
Value : = 150 mg/kg bw
Species : mouse
Strain :
Sex :
Number of animals :
Vehicle :
Doses :
Route of admin. : s.c.
Exposure time :
Method : other
Year :
GLP : no data
Test substance : no data
Remark : Mice received a single subcutaneous injection of p-cresol.
No further experimental details are available in the citing
reference (Sternitzke et al. 1992).
22.03.2001 (143) (144)
5.2.1 SKIN IRRITATION
Species : rabbit
Concentration : undiluted
Exposure : Semiocclusive
Exposure time : 4 hour(s)
Number of animals : 6
Vehicle :
PDII :
Result : corrosive
Classification :
Method : other: see freetext ME
UNEP PUBLICATIONS 259