m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Method : other: according to Ames,Proc.Natl.Acad.Sci.70, 2281(1973);
Mutat.Res.31,347(1975);
Nestmann,Cancer Res.39.4412(1979); Environ.Mutagen.1,361(1979)
Year : 1980
GLP : no data
Test substance : other TS: m-cresol from commercial source (Aldrich)
Remark : According to the authors the result was "presumably negative, but solubility
did not allow the testing of the compound in amounts that result in bacterial
toxicity"
Metabolic activation: with and without (liver S-9 mix from Aroclor 1254
induced rats)
Reliability : (2) valid with restrictions
limited documentation
17.12.2002 (134)
Type : Ames test
System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537
Test concentration : no data
Cycotoxic concentr. :
Metabolic activation : with and without
Result : negative
Method : other: according to Ames, Mutation Res. 31, 347 (1975)
Year : 1980
GLP : no data
Test substance : other TS: no data on purity
Reliability : (4) not assignable
documentation insufficient for assessment
20.09.2002 (135)
Type : Unscheduled DNA synthesis
System of testing : rat primary hepatocytes
Test concentration : 502, 251, 100, 50.2, 25.1, 10.0, 5.02, 2.51, 1.0, 0.502 ug/ml in DMSO
Cycotoxic concentr. : concentration range: 502 - 25.1 ug/ml: excessive toxicity
Metabolic activation : without
Result : negative
Method : other: OECD Guide-line 482, see freetext ME with additional informations
Year : 1988
GLP : yes
Test substance : other TS: m-cresol, purity: 99.8 %
Method : DOSE SELECTION: Doses were chosen following a preliminary
experiment
SOLVENT: DMSO
CONTROLS: solvent and 1-acetylaminofluorene (2-AAF) served as
negative and positive controls, respectively
EVALUATION CRITERIA: a dose related increase of at least 6 grains per
nucleus after subtraction of the concurrent negative control value
Result : m-Cresol was evaluated as not causing UDS in cultured rat hepatocytes.
The positive control was functional.
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (136)
Type : Sister chromatid exchange assay
System of testing : cultured male human fibroblasts
Test concentration : 0, 0.08, 0.8, 4, 8 mM dissolved in ethanol; 10, 30 mM dissolved in Eagle's
Minimal Essential Medium (MEM)
Cycotoxic concentr. : > 8 mM cytotoxic response
Metabolic activation : without
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