m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Year :
GLP : no data
Test substance : no data
Remark : The individual cresol isomers cause severe irritation when
applied directly to the cornea. Mice exposed to high
atmospheric concentrations of "cresylic acid vapours"
suffered eye irritation. The original data for the former
effect are unpublished and available from the US EPA
Freedom of Information Office. No further details are
available in the citing reviews. The latter findings were
reported in a 1941 study using Shell cresylic acids;
apparently not cresols themselves (Campbell, 1941).
Reliability : (4) not assignable
Review
13.12.2002 (145) (146) (147) (129)
Species : rabbit
Concentration : undiluted
Dose : .1 ml
Exposure time : unspecified
Comment :
Number of animals : 6
Vehicle :
Result : highly irritating
Classification :
Method : other: 0.1 ml undiluted TS, time of reading: 24, 48, 72 hrs
Year : 1969
GLP : no data
Test substance : other TS: p-cresol, M.P.: 36 C, B.P.: 202 C
Remark : 24 hours: cornea, iris, conjunctivae: 84.7/110 (mean score)
mean score for cornea: 60; mean score for iris: 10; mean score for
conjunctivae: 14.7)
48 hours: cornea, iris, conjunctivae: 89.7/110 (mean score)
mean score for cornea: 63.3, mean score for iris: 10, mean score for
conjunctivae: 16.3)
72 hours: cornea, iris, conjunctivae: 93.0/110 (mean score)
mean score for cornea: 66.6, mean score for iris: 10; mean score for
conjunctivae: 16.3)
summary: irritation score: 93.0/110
Reliability : (2) valid with restrictions
no information on GLP, strain used
Flag : Critical study for SIDS endpoint
06.02.2004 (139)
5.3 SENSITIZATION
Type : other: maximization test
Species : human
Number of animals :
Vehicle : petrolatum
Result : not sensitizing
Classification :
Method : other: see freetext ME
Year : 1966
GLP : no data
Test substance : other TS: p-cresol, purity not noted
Method : A maximization test was conducted on 25 volunteers using a
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