m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
3.1.3 Irritation
Skin Irritation
There is no study according to the current OECD Test guideline, but the available studies are
adequately documented and are considered of sufficient quality to allow an evaluation of this
endpoint:
m-Cresol:
Application of 0.5 ml of the undiluted liquid to the intact or abraded skin of each of 6 rabbits caused
within 24 hours severe erythema and edema in each rabbit, which did not disappear within the 72
hours observation time (mean score value: 8.00/8.00) (BioFax 1969a). Using semi-occlusive
dressing for 4 hours, the visible tissue damage was indicative of corrosive effects (Vernot et al.
1977).
p-Cresol:
Application of 0.5 ml of the undiluted liquid to the intact or abraded skin of each of 6 rabbits caused
within 24 hours severe erythema and edema in the skin of each rabbit, which did not disappear
within the 72 hours observation time (mean score value: 8.00/8.00) (BioFax 1969b). Using semiocclusive
dressing for 4 hours, the visible tissue damage was indicative of corrosive effects (Vernot
et al. 1977).
Application of 0.5 % p-cresol to the skin for 6 weeks resulted in permanent depigmentation of the
skin and hair in black and agouti mice (Shelley 1974).
m/p-Cresol:
Undiluted m/p-cresol mixture was applied to the clipped intact skin of three male and female rabbits
for four hours covered by semiocclusive dressing and evaluated as corrosive because necrosis with
severe edema was noted 4 hours post application and eschar formation developed within 24 hours
(Younger Lab 1974).
Conclusion:
m-Cresol, p-cresol and m/p-cresol mixtures are corrosive to the skin.
Eye Irritation
m-Cresol:
0.1 ml of the undiluted liquid caused highly irritating effects in the cornea, iris and conjunctivae of
all 6 treated rabbits. There was no recovery during the 72 hours observation period, and the mean
irritation score at 72 hours was 87.3/110 (BioFax 1969a).
p-Cresol
0.1 ml of the undiluted liquid caused highly irritating effects in the cornea, iris and conjunctivae of
all 6 treated rabbits. The effects did increase in severity during the 72 hours observation period, and
the mean irritation score at 72 hours was 93.0/110 (BioFax 1969b).
m/p Cresol:
There is no study available using a m/p-Cresol-mixture.
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