m-Cresol - ipcs inchem

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OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 Remark : In female CFY rats, the excretion of m-cresol in urine was increased after exposure to xylene (4000 mg/m3/6 h). Reliability : (4) not assignable 16.01.2003 (186) Type : Metabolism Remark : The retention of m-cresol in male Wistar rats after the oral administration of 25 ug/rat for 3 d (test period 7 d) was 0.2 % (percentage of applied dose). Reliability : (4) not assignable 16.01.2003 (26) Type : Metabolism Remark : After an oral application of 10 g m-cresol within 3 days to one dog the substance was excreted unchanged in urine. Reliability : (4) not assignable 16.01.2003 (187) Type : Metabolism Remark : In an in vitro study m-cresol was hydroxylated to 2,5-dihydroxytoluene and probably to the sulfate conjugate of m-hydroxybenzyl alcohol with rat liver homogenate and slices. Reliability : (4) not assignable 16.01.2003 (188) Type : Metabolism Remark : in vitro: Metabolic cooperation assay for gap junctional intercellular communication with chinese hamster cells (V79): negative. Reliability : (4) not assignable 16.01.2003 (189) Remark : m-cresol inhibited the growth of chick embryo fibroblasts (incubation for 24 h), the sublethal dose was approx. 20 mg/l and the lethal dose > 20 < 50 mg/l. Reliability : (4) not assignable 16.01.2003 (78) Remark : m-cresol (0.5 or 1.0 ml) showed an inhibitory effect on the ATP-induced (50 ug) pulmonary vasoconstriction in isolated perfused rabbit lungs. Reliability : (4) not assignable 16.01.2003 (190) Remark : m-cresol (550 mg/m3) showed a ciliostasis index of 0.7 to 0.75 in isolated rabbit tracheal tissue. Reliability : (4) not assignable 16.01.2003 (191) Remark : In a neutral red (NR) cytotoxicity assay with Bluegill sunfish BF-2 cells, the NR50 was determined with 5.3 mM. 160 UNEP PUBLICATIONS
OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 Reliability : (4) not assignable 16.01.2003 (192) Remark : In male Sprague-Dawley rats no effect on oxygen consumption was observed after a single i.p. injection of 50-200 mg/kg bw. Reliability : (4) not assignable 16.01.2003 (193) (194) Remark : In vitro short term cytotoxicity tests: I. method: inhibition of cell growth in ascites sarcoma BP8 cells (concentration 1mM, incubation for 48 hours) I. result: the inhibitory effect was >= 30 = 60 = 30 = 70
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS p-CRESOL 3. ENVIRONMENTAL
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OECD SIDS p-CRESOL 4. ECOTOXICITY I
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OECD SIDS p-CRESOL 6. REFERENCES ID
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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