m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
Table 6:
p-Cresol: Repeated Dose Toxicity: Rat/Mouse
Study Description NOAEL Effects Reference
Rat
5 rats/sex/dose, 28 d feeding
0, 300, 1000, 3000, 10,000,
30,000 ppm
(m:0, 25, 87, 256, 835, 2180
mg/kg bw/day;
f: 0, 25, 83, 242, 769, 2060
mg/kg bw/day)
Systemic:
1000 ppm (m:
87 mg/kg
bw/day, f: 83
mg/kg
bw/day) and
1000 ppm
(local)
No mortality
30,000 ppm,m,f: decreased feed consumption,
decreased bw gain and final bw; hunched posture,
rough hair coat, increased rel. liver and kidney weight,
uterus atrophy in 3 of 5 females; no histopathological
changes in liver or kidney.
≥10,000 ppm: increased rel liver, mild bone marrow
hypocellularity, in males increased rel kidney weight,
NTP 1991
≥3000 ppm: effects in nasal cavity indicative of
irritation; mild bone marrow hypocellularity in 1 of 5
males, increased rel liver weight in females
30 rats/sex/dose, 13 w gavage
0, 50, 175, 600 mg/kg bw/day in
corn oil
50 mg/kg
bw/day
600 mg: in females death of 3 animals, lethargy,
salivation, tremor, convulsion, decreased body weight
gain, decreased food consumption (m), increased
SGPT (f) and SGOT (f), decreased ovary weight,
increased rel. liver weight (m) and increased rel
kidney weight, effects on trachea indicative of
irritation
≥175 mg : decreased body weight gain (m), increased
serum protein (m), decreased red blood cell count, Hb-
, hematocrit-values (f)
Microbiolo
gical
Associates
Inc 1988b
chronic nephropathy in all male animals, including the
controls
10 rats/sex/dose, , 13 w gavage
20 rats/sex as control
0, 50, 175, 600 mg/kg bw/day in
corn oil
neurotoxicity study
available as summary only
Mouse
5 mice/sex/dose, 28 d feeding
0, 300, 1000, 3000, 10,000,
30,000 ppm
(m.: 0, 50, 163, 469, 1410, n.d.*
mg/kg bw/day;
f.: 0, 60, 207, 564, 1590,n.d.*
mg/kg bw/day)
* not determined
* 600 mg: increased mortality (4m and4f; due to
aspiration), reduced body weight gain (m), reduced
food consumption, reduced locomotor activity
1000 ppm
(systemic;
163/207
mg/kg
bw/day)
300 ppm
(local; m)
< 300 ppm
(local, f)
≥ 50 mg: clinical signs as salivation, tremor, urine wet
abdomen, hypoactivity, myoclonus, rapid and labored
respiration, hyperreactivity
30,000 ppm: death of all dosed mice: renal and hepatic
necrosis, bone marrow hypocellularity and renal
tubular necrosis and liver cell necrosis; in females
hunched posture, rough hair coat, lethargy,
hypothermia, laboured breathing, paleness
10,000 ppm: 1 m died,
in males hunched posture, rough hair coat, lethargy,
hypothermia, laboured breathing, paleness, lowered
bw gain and final bw, depressed food consumption at
the beginning; rel. liver- and heart-weight increased,
in females depressed food consumption
TRL 1986
NTP 1991
≥3000 ppm, in females rel. liver weight increased, in
males rel. kidney weight increased
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