m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
≥300 ppm, f and ≥1000 ppm, m: nasal lesions
indicative of irritation
* due to limitations in the study documentation, NOAELs were not derived
Table 7:
m/p-Cresol (60:40): Repeated Dose Toxicity: Rat
Study Description NOAEL Effects Reference
Rat
5 rats/sex/dose, 28 d, feeding
0, 300, 1000, 3000, 10,000,
30,000 ppm
(m: 0, 26, 90, 261, 877, 2600
mg/kg bw/day
f: 0, 27, 95, 268, 886,2570
mg/kg bw/day)
Systemic:
1000 ppm
(m;90
mg/kg
bw/day; f;
95 mg/kg
bw/day)
No mortality
30,000 ppm, m, f: reduced bw gain, reduced food
consumption, thin appearance, bone marrow
hypocellularity, no histopathological changes in liver or
kidney
NTP 1991
300 ppm
(local)
≥ 10,000 ppm,f: increased rel. liver and kidney weight,
local effects at forestomach (m)
≥ 3000 ppm: slightly increased rel. liver weight, (m,f)
increased colloid within follicles of the thyroid gland.
effects on oesophagus and forestomach (f only)
indicative of irritation
≥ 1000 ppm (f) and ≥ 3000 ppm (m): effects in the
nasal cavity indicative of irritation
20 rats/sex/dose, 13 week
feeding
0, 1880, 3750,7500, 15,000,
30,000 ppm,
(m: 0, 123, 241, 486, 991, 2014
mg/kg bw/day; f: 0, 131, 254,
509, 1024, 2050 mg/kg bw/day)
Males:
1880 ppm
females:
3750 ppm
(systemic,
123/254
mg/kg
bw/day)
No mortality
30,000 ppm: rough hair coat , urine stained fur, and
thin appearance (f only), reduced feed consumption,
increased rel kidney weights (f), bone marrow
hypocellularity (f), decreased 5'Nucleotidase, increased
serum bile acids; no histopathological changes in liver
or kidney
NTP 1991
< 1880 ppm
(local)
≥ 15,000 ppm reduced terminal body weight and
decreased body weight gain(f only), increased rel testes
weight, bone marrow hypocellularity (m), uterus
atrophy, increased colloid within thyroid follicles
≥7500 ppm: increased rel liver weight and kidney
weight (m), increased colloid within thyroid follicles (f
only), lengthened oestrous cycle
≥3750 ppm: increased abs. liver weight (m)
≥1880 ppm: histological changes in nasal epithelium
indicative of irritation
UNEP PUBLICATIONS 23