m-Cresol - ipcs inchem

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OECD SIDS p-CRESOL 4. ECOTOXICITY ID: 106-44-5 DATE: 24.05.2004 Unit : mg/l EC50 : = 160 Analytical monitoring : No Method : Year : 1985 GLP : no data Test substance : other TS: p-cresol; purity analytical grade Method : The test was carried out under sterile conditions. T. pyriformis was pre-cultured at 30 degree C for 24 hours. The stock solution of chemical was added to the sterile medium to provide a constant ratio of 1.8 in 10 ml of 2% protose peptone. The solutions were then inoculated with 0.2 ml T. pyriformis and cultivated for 24 hours at 30 degree C without agitation. The number of cells were counted manually under a microscope (repeated 3 times) and with a Coulter Counter, Model Zb (repeated twice). Mean values were recorded with each method. Correlation coefficient between manual and Couter Counter was 0.998. Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 24.10.2001 (110) Type : Aquatic Species : other bacteria: Aerobic heterotrophs Exposure period : 49 hour(s) Unit : mg/l IC50 : = 260 Analytical monitoring : No Method : Year : 1991 GLP : No Test substance : other TS: p-cresol, no purity reported Method : culture obtained from mixed liquor of a treatment plant Remark : Effect: inhibition of respiration; prolonged incubation compared with ISO 8192 Test condition : 25 and 35 degrees C Reliability : (2) valid with restrictions Study in accordance with generally accepted scientific standards and described in sufficient detail 07.05.2004 (107) Type : Aquatic Species : other bacteria: Methanogenic bacteria Exposure period : 96 hour(s) Unit : mg/l IC50 : = 91 Analytical monitoring : No Method : other: Owen, W.F.: Bioassay for Monitoring Biochemical Methane Potential and Anaerobic Toxicity. Water Res. 13, 485 (1979) Year : 1991 GLP : No Test substance : other TS: p-cresol, no purity reported Remark : Effect: Inhibition of gas production (CH4 + CO2) Test condition : 35 degrees C Reliability : (2) valid with restrictions Study in accordance with generally accepted scientific 240 UNEP PUBLICATIONS
OECD SIDS p-CRESOL 4. ECOTOXICITY ID: 106-44-5 DATE: 24.05.2004 standards and described in sufficient detail 07.05.2004 (107) Type : Aquatic Species : Escherichia coli (Bacteria) Exposure period : Unit : mg/l TT : > 1000 Analytical monitoring : No Method : Year : 1960 GLP : No Test substance : other TS: p-cresol, no purity reported Method : test organisms isolated from river water endpoint: inhibition of glucose metabolism Remark : TT = toxicity treshold; determined at 5% effect compared to control Reliability : (3) invalid Experimental details missing 07.05.2004 (111) Type : Aquatic Species : Photobacterium phosphoreum (Bacteria) Exposure period : 15 minute(s) Unit : mg/l EC50 : = 1.6 Analytical monitoring : No Method : other: Microtox assay Year : 1987 GLP : No Test substance : other TS: p-cresol, analytical grade (either from Merck or EGA Chemie) Remark : Not enough information supplied for assessment of the test used (Test done according to Beckman manual). Although it is suggested that Microtox may lack reproducibility due to variations in bacterial cell suspensions [Bitton G (1983) Bacterial and Biochemical Tests for Assessing Chemical Toxicity in the Aquatic Environment: A Review. Crit Rev Environ Control 13: 51 -67], no information is supplied on the maintenance of the lyophilized bacteria, their age, duration of reconstitution and other important parameters. Reliability : (3) invalid Unsuitable test system. Organisms are of marine origin. Method is not appropriate for the hazard assessment of chemicals. 07.05.2004 (112) Type : Aquatic Species : Photobacterium phosphoreum (Bacteria) Exposure period : 30 minute(s) Unit : mg/l EC50 : = 1.5 Analytical monitoring : No Method : other: Microtox assay Year : 1981 GLP : no data Test substance : other TS: p-cresol, no purity reported Remark : Inhibition of bioluminescence Secondary literature; not enough information for assessment of cited result Test condition : 20 degrees C Reliability : (4) not assignable UNEP PUBLICATIONS 241
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS p-CRESOL 1. GENERAL INFOR
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OECD SIDS p-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS p-CRESOL 6. REFERENCES ID
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OECD SIDS p-CRESOL 6. REFERENCES ID
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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