m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Females :
Vehicle :
Method :
Year :
GLP :
Test substance : other TS: p-cresol, not specified further
Result : Daily excretion rates of p-cresol were measured on 24-hr urine collections
from 4 healthy weman and 6 healthy men ages 21 to 46: women: 59.0
(35.0-75.0) mg/day; men: 46.8 (36.7-56.8) mg/day
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
06.02.2004 (133)
In Vitro/in vivo : In vitro
Type : Metabolism
Species : other: male rat liver slices
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle : other: DMSO
Method :
Year :
GLP :
Test substance : other TS: p-cresol, not specified further
Method : Precision-cut liver slices were prepared from male Sprague-Dawley rats
and incubated in Krebs-Hepes buffer for up to 6 hours. Metabolism studies
were carried out using 1mM concentration of p-cresol for a period of 1 hour
and 1 mM glutathione was added. Supernatants from each slice were
analyzed for glutathione conjugates directly by HPLC.
Result : In slices, p-cresol formed a glutathione conjugate at a rate of 2.31
nmol/h/slice which support evidence of formation of quinone methide as
intermediate.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
06.02.2004 (134)
In Vitro/in vivo : In vivo
Type : Metabolism
Species : human
Number of animals
Males : 5
Females : 5
Doses
Males :
Females :
Vehicle :
Remark : Urine was collected from 5 women and 5 men during a period of 24 hours
who were eating self-selected diets. The 24 hours excretions of p-cresol
were 59.7 mg/24 h and 73.9 mg/24 h for males and females, respectively.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
16.01.2003 (135)
UNEP PUBLICATIONS 253