m-Cresol - ipcs inchem

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OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 Solvent: DMSO CONTROL: DMSO and Mitomycin C, cyclophosphamide served as negative and positive control, respectively STATISTICAL ANALYSIS: Fisher's Exact Test with an adjustment for multiple comparisons Remark : The positive controls were functional Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 06.02.2004 (148) Type : Unscheduled DNA synthesis System of testing : other: Syrian Hamster Embryo (SHE) cells Test concentration : 1, 3, 10 uM, vehicle: medium Cycotoxic concentr. : not determined Metabolic activation : with and without Result : positive Method : other: according to OECD Guide-line 482: not tested up to cytotoxicity Year : 2000 GLP : no data Test substance : other TS: m-cresol, purity: >=98 % Result : A dose-dependent positive result was only obtained when tested in the presence of a metabolic activation system. It was not tested up to cytotoxicity. Reliability : (2) valid with restrictions not tested up to cytotoxic concentration, no data on GLP, no positive or negative controls reported Flag : Critical study for SIDS endpoint 06.02.2004 (149) 5.6 GENETIC TOXICITY ‘IN VIVO‘ 146 Type : Cytogenetic assay Species : other: mouse bone marrow cells Sex : male/female Strain : ICR Route of admin. : gavage Exposure period : once Doses : 0, 96, 320, 960 mg/kg bw in corn oil Result : negative Method : other: in accordance with OECD Guideline 475, 5 mice/sex/dose, bone marrow cells, sacrifice 6,24,48 hrs post treatment, negative and positive controls, stat. method: Kruskal-Wallis test Year : 1989 GLP : yes Test substance : other TS: m-cresol, purity: 99.8 % Remark : dose finding study: see chapter 5.1.1 CONTROL: corn oil and cyclophphamide served as negative and positive control EVALUATION CRITERIA: positive response is indicated by statistically significant dose-related increase in the number of structural aberrattions at 3 dose levels Result : The treatment did not increase the frequency of chromosomal aberrations, indicating that m-cresol was not clastogenic under the conditions of this assay. The positive control was functional mortality: 3/5 male mice in the 960 mg-group signs of toxicity: 960 mg-group: within 10 min after dosing: squinty eyes, scruffy coats, mild tonic convulsions and rapid breathing which ceased after 30 min., UNEP PUBLICATIONS
OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 breathing difficulties 320 mg/kg bw: slightly scruffy coats within 22 hours after dosing 96 mg/kg bw: no signs of toxicity Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 06.02.2004 (150) Type : Sister chromatid exchange assay Species : mouse Sex : male Strain : DBA Route of admin. : i.p. Exposure period : single application Doses : 0, 200 mg/kg bw dissolved in sunflower oil Result : negative Method : other: see freetext ME Year : 1984 GLP : no data Test substance : other TS: m-cresol, purity: 99 % Method : m-<strong>Cresol</strong> was administered to 2 or 3 intact or hepatectomized male mice by single intraperitoneal injection. After 30 min, DNA labelling was initiated using BrdU. After a further 21 hr the animals were killed, cells isolated and harvested and sister chromatid exchange (SCE) frequency in bone marrow cells, alveolar macrophages and regenerating liver cells analysed. Some of the mice were partially hepatectomized to induce liver cell regeneration NEGATIVE CONTROLS: 0.35 ml sunflower oil (4 intact and 5 hepatectomized male mice, bone marrow cells, alveolar macrophages, liver cells) Positive Control: 5 mg cyclophosphamide/kg bw (2 intact male mice, bone marrow cells and alveolar macrophages) STATISTICAL ANALYSIS: One way analysis of variance; Dunnett's test for comparison Result : No increase in SCE frequencies in the intact mice as well as in the partially hepatectomized mice. The dose tested was overtly toxic to the mice, causing lethargy, piloerection and lacrimation. The positive control was functional Reliability : (2) valid with restrictions only one dose tested and no information on GLP 06.02.2004 (137) 5.7 CARCINOGENICITY Species : mouse Sex : female Strain : other: Sutter Route of admin. : dermal Exposure period : 12 w (I) or 20 w (II) Frequency of treatm. : twice weekly Post exposure period : no Doses : 25 ul of a 20 % (I) or 5.7 % (II) solution in benzene Result : Control group : yes, concurrent vehicle Method : other: Initiation-promotion test (see remarks) Year : 1959 GLP : no Test substance : other TS: m-cresol, not specified further Remark : Groups of 20-29 Sutter strain mice: UNEP PUBLICATIONS 147
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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