m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
temperature: 72° +/-3° F, humidity: 50 % +/-15 %, Fluorescent light: 12
hrs/day, room air changes : 10-12 changes/hr
TYPE AND FREQUENCY OF OBSERVATION:
observed twice daily, body weight taken initially, weekly, and at termination,
feed consumption by cage recorded twice weekly
NECROPSY AND HISTOLOGIC EXAMINATION:
necropsy and tissue collection performed for all animals. A complete
histopathologic examination was conducted on all control animals, all
animals in the highest dose group with at least 60 % survivors at study
termination, and all aninmals in higher dose groups inclusive of early
deaths. The following organs and/or tissues were included in complete
histopathological examinations, as well as any tissue masses, gross
lesions, and associated regional lymph nodes: adrenals, aorta, bone
(sternebrae, femur, or vertebrae, including marrow), brain, bronchi, clitoral
gland, epididymis, oesophagus, gallbladder, heart, kidney, large intestines
(caecum, colon, rectum), liver, lungs, lymph nodes (mesenteric), mammary
glands, nasal cavity and turbinates, oral cavity, ovaries, pancreas,
parathyroids, pharynx, pituirary, preputial gland, prostate, salivary glands,
scrotal sac, seminal vesicles, skin, small intestine (duodenum, ileum,
jejunum), spleen, stomach, testes, thymus, thyroid, tongue, trachea, tunica
vaginalis, urinary bladder, uterus and Zymbal's glands. Target organs and
gross lesions were examined at lower doses until a no-observed chemical
effect was determined. Target organs included the following: uterus and
ovaries and mammary gland. Organ weights recorded for brain, liver, right
kidney, thymus, heart, and lungs of all animals, and the right testis of all
males.
STATISTICAL METHODS:
nonparametric multiple comparison test of Dunn and Shirley,
Jonckheere's test
Remark : mean compound consumption (mg/kg bw/day):
males females
0 ppm 0 0
300 ppm 53 66
1000 ppm 193 210
3000 ppm 521 651
10000 ppm 1730 2080
30000 ppm 4710 4940
Result : mortality:
0 ppm: 1/5 male; 10000 ppm: 1/5 females; 300000 ppm: 2/5
males, 2/5 females;
Signs of toxicty:
at 30000 ppm: male, female;
hunched posture, rough hair coat, thin appearance, lethargy and
tremor,hypothermia (only females),
at 10000 ppm: males and females, hunched posture, rough hair coat,
females only: laboured respiration lethaty, sunken eyes
final mean body weight reduced at 30000 ppm in males (p