m-Cresol - ipcs inchem

More documents

Recommendations

Info

OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 Year : 1991 GLP : yes Test substance : other TS: p-cresol, Purity > 98 % Result : Histopathological examination revealed no effects on the reproductive organs. Reliability : (1) valid without restriction 06.02.2004 (150) Type : other In vitro/in vivo : In vivo Species : rat Sex : male/female Strain : Sprague-Dawley Route of admin. : gavage Exposure period : 134 weeks Frequency of treatm. : daily Duration of test : 14 weeks Doses : 0, 50,175, 600 mg/kg bw dissolved in corn oil Control group : yes, concurrent vehicle Result : 600 mg-gr.: death of 3 females, decreased ovary weights; males: increased testes weight Method : other: the reproductive organs were examined as part of the 13 week toxicity study, see chapter 5.4 Year : 1986 GLP : yes Test substance : other TS: p-cresol, purity 99.9 % Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 06.02.2004 (151) 5.9 SPECIFIC INVESTIGATIONS 282 Endpoint : Neurotoxicity Study descr. in chapter : 5.9 Specific Investigations Reference : Type : other: subchronic Species : rat Sex : male/female Strain : other: CD Route of admin. : gavage No. of animals : 20 Vehicle : other: corn oil Exposure period : 90 day(s) Frequency of treatm. : once daily Doses : 0, 50, 175, 600 mg/kg bw Control group : yes, concurrent vehicle Observation period : 13 weeks during dosing Result : see freetext RS Method : other: see freetext ME Year : 1986 GLP : no data Test substance : other TS: purity: no data Method : 10 male and 10 female CD rats/treatment group received corn oil solutions of 50, 175 or 600 mg/kg bw /day by gavage once daily for 13 weeks. 20 male and 20 female CD rats received corn oil alond to serve as control.Rats were observed for body weight gain, food consumption, clinical signs. UNEP PUBLICATIONS
OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 Signs of neurobehavioral toxicity were documented during pretreatment, 1 and 6 hours after dosing on study day 1 and prior dosing on study days 2, 7, 14, 30, 60 and 90 including salivation, urination, tremors, piloerection, diarrhea, pupil size, pupil response, lacrimation, hypothermia, vocalization, exophthalmus, palpebral closure, convulsions (type and severity), respiration (rate and type), impaired gait, positional passivity, locomotor activity, stereotypy, startle response, righting reflex, performance on a wire maneuver, forelimb grip strength, positive geotropism, extensor thrust, limb rotation, tail pinch reflex, toe pinch reflex, hind limb splay. gross and histopathologic examination Result : Mortality: control: 1 female(2.5 %), 600 mg-gr: 4 males and 4 females (40 %), gross and histopathologic examination: aspiration or inhalation of the TS, pulmonary edema body weight gain: 600 mg-gr., males less than control during week 1 mean food consumption, 600 mg-gr., males and females: significantly less than control clinical signs: dose related in incidence: salivation, myotonus, tremors, urine wet abdomen, hypoactivity, rapid respiration neurobehavioral toxicity: 600 mg-group, males and females: initial part of the study: incidence of palpebral closure, rales, laboured respiration; locomotor activity less than concurrent controls; at study termination: a trend towards increased urination. Other differences from controls with regard to behavioral tests were evaluated as sporadic in nature by the authors (no further details given). necropsy: brain weights of treated animals comparable to controls; gross and microscopic examination of tissues revealed no lesions which were attributable to treatment Reliability : (2) valid with restrictions limited documentation (only study summary available) Flag : Critical study for SIDS endpoint 04.02.2004 (145) (129) (171) 5.10 EXPOSURE EXPERIENCE Remark : In vitro production of p-cresol from tyrosine by bacteria isolated from normal human gut was examined. Strictly anaerobic and facultatively anaerobic bacteria were grown at 37oC in the presence of 0.01% tyrosine for 72 and 48 hr respectively. The growth atmospheres for the bacteria were nitrogen, hydrogen and carbon dioxide and air respectively. p-Cresol production from tyrosine was seen with the strictly anaerobic gut bacteria but not the facultatively anaerobic bacteria. p-Cresol is, therefore, produced endogenously from tyrosine, an amino acid present in most proteins, by strictly anaerobic bacteria in the intestine. According to the results of studies in cancer patients, endogenous p-Cresol does not contribute significantly to the development of large bowl caner (18 patients versus 10 normal healthy persons. Reliability : (2) valid with restrictions Flag : Critical study for SIDS endpoint 15.01.2003 (133) Remark : The probable oral lethal dose for humans is 50-500 mg/kg bw. Reliability : (2) valid with restrictions Flag : Critical study for SIDS endpoint 10.01.2003 (172) UNEP PUBLICATIONS 283
Page 1 and 2:
OECD SIDS m- / p-CRESOL FOREOWRD IN
Page 3 and 4:
OECD SIDS m- / p-CRESOL 11. Comment
Page 5 and 6:
OECD SIDS m- / p-CRESOL of mice. In
Page 7 and 8:
OECD SIDS m- / p-CRESOL SIDS Initia
Page 9 and 10:
OECD SIDS m- / p-CRESOL Table 3: Es
Page 11 and 12:
OECD SIDS m- / p-CRESOL m-cresol an
Page 13 and 14:
OECD SIDS m- / p-CRESOL extensive s
Page 15 and 16:
OECD SIDS m- / p-CRESOL et al. 1993
Page 17 and 18:
OECD SIDS m- / p-CRESOL study in wh
Page 19 and 20:
OECD SIDS m- / p-CRESOL Conclusion:
Page 21 and 22:
OECD SIDS m- / p-CRESOL Table 5: m-
Page 23 and 24:
OECD SIDS m- / p-CRESOL ≥300 ppm,
Page 25 and 26:
OECD SIDS m- / p-CRESOL Atrophy and
Page 27 and 28:
OECD SIDS m- / p-CRESOL p-Cresol p-
Page 29 and 30:
OECD SIDS m- / p-CRESOL 3.1.7 Carci
Page 31 and 32:
OECD SIDS m- / p-CRESOL weights wer
Page 33 and 34:
OECD SIDS m- / p-CRESOL drowsiness,
Page 35 and 36:
OECD SIDS m- / p-CRESOL and reduced
Page 37 and 38:
OECD SIDS m- / p-CRESOL The most se
Page 39 and 40:
OECD SIDS m- / p-CRESOL Table 14: T
Page 41 and 42:
OECD SIDS m- / p-CRESOL Table 15: T
Page 43 and 44:
OECD SIDS m- / p-CRESOL 5 RECOMMEND
Page 45 and 46:
OECD SIDS m- / p-CRESOL BRRC (Bushy
Page 47 and 48:
OECD SIDS m- / p-CRESOL Hamster Ova
Page 49 and 50:
OECD SIDS m- / p-CRESOL Nobel W, Ma
Page 51 and 52:
OECD SIDS m- / p-CRESOL Vernot EH,
Page 53 and 54:
OECD SIDS m- / p-CRESOL Available P
Page 55 and 56:
OECD SIDS m- / p-CRESOL √ informa
Page 57 and 58:
OECD SIDS m-CRESOL 1. GENERAL INFOR
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
OECD SIDS m-CRESOL 3. ENVIRONMENTAL
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
OECD SIDS m-CRESOL 4. ECOTOXICITY I
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
OECD SIDS m-CRESOL 5. TOXICITY ID:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
OECD SIDS m-CRESOL 6. REFERENCES ID
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
OECD SIDS p-CRESOL 1. GENERAL INFOR
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
OECD SIDS p-CRESOL 2. PHYSICO-CHEMI
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
OECD SIDS p-CRESOL 3. ENVIRONMENTAL
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
OECD SIDS p-CRESOL 4. ECOTOXICITY I
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232: OECD SIDS p-CRESOL 4. ECOTOXICITY I
Page 249 and 250: OECD SIDS p-CRESOL 5. TOXICITY ID:
Page 281: OECD SIDS p-CRESOL 5. TOXICITY ID:
Page 287 and 288: OECD SIDS p-CRESOL 6. REFERENCES ID
Page 295 and 296: OECD SIDS m- / p-CRESOL MIXTURE I U
Page 297 and 298: OECD SIDS m- / p-CRESOL MIXTURE 1.
Page 333 and 334:
OECD SIDS m- / p-CRESOL MIXTURE 4.
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347 and 348:
Page 349 and 350:
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Page 363 and 364:
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
Page 371 and 372:
Page 373 and 374:
Page 375 and 376:
Page 377:
show all

m-Cresol - ipcs inchem

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?