m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
decedents, gross necropsy: inflammation of the
gastrointestinal tract, hyperemia of lungs, liver and
kidneys
Reliability : (2) valid with restrictions
no information on strain used , no information on statistical evaluation given
Flag : Critical study for SIDS endpoint
06.02.2004 (116) (117)
Type : LD50
Value : = 2020 mg/kg bw
Species : rat
Strain : Wistar
Sex : male/female
Number of animals : 10
Vehicle : other: olive oil
Doses : 1500, 1700, 2000, 2200, 2400 mg/kg bw
Method : other: 5 rats/sex/dose, 6 doses, administration as a 10% solution in olive oil
to non-fasted Wistar rats by gavage to give doses of 1500-2700 mg/kg bw,
observation time was not reported, section was not performed
Year : 1944
GLP : no data
Test substance : other TS:m-cresol, purity: 96-98 %
Result : 1500 mg/kg: 0 % dead, 1700 mg/kg: 20 % dead, 2000 mg/kg: 40 % dead,
2200 mg/kg: 70 % dead, 2400 mg/kg: 70 % dead,
time of death not mentioned
signs of poisoning: twitching of isolated bundles of muscles and
uncoordinated movement of the legs, irregular pulse and difficulties in
breathing
Reliability : (2) valid with restrictions
post-exposure observation time not reported
Flag : Critical study for SIDS endpoint
06.02.2004 (118)
Type : LD50
Value : = 2010 mg/kg bw
Species : rat
Strain : no data
Sex : no data
Number of animals :
Vehicle : other: oil
Doses : no data
Method : other: 10 % solution was used
Year : 1974
GLP : no data
Test substance : other TS: m-cresol, not specified further
Reliability : (4) not assignable
secondary citation
06.02.2004 (112) (119)
Type : LD50
Value : = 520 mg/kg bw
Species : rat
Strain :
Sex : male
Number of animals : 10
Vehicle : water
Doses :
Method : other: 10 rats/ dose were fed with a 10 % aqueous solution, 5 doses,
observation period: 14 d, gross examination
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