m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
Sex : male/female
Strain : other: F334/N
Route of admin. : oral feed
Exposure period : 13 w
Frequency of treatm. : continuously in feed
Post exposure period : no
Doses : 0, 1880, 3750, 7500, 15000, 30000 ppm (see RM)
Control group : yes, concurrent no treatment
NOAEL : 3750 ppm
Method : other: see freetext ME
Year : 1991
GLP : yes
Test substance : other TS: m-/p-cresol (60%:40% mixture)
Method : SIZE OF STUDY GROUP:
20 male and 20 female rats (10 of each group designated for
clinical pathology studies)
TIME HELD BEFORE STUDY: 12-13 days
METHOD OF ANIMAL DISTRIBUTION:
randomized for each sex on the basis of body weight into
groups per sex
DIET: NIH-07 rat ration
ANIMAL ROOM ENVIRONMENT:
temperature: 72° +/-3° F, humidity: 50 % +/-15 %,
Fluorescent light: 12 hrs/day, room air changes: 10-12
changes/hr
TYPE AND FREQUENCY OF OBSERVATION:
observed twice daily, body weight taken initially, weekly,
and at termination, feed consumption by cage recorded twice
weekly
NECROPSY AND HISTOLOGIC EXAMINATION:
necropsy performed on all animals. A complete
histopathologic examination was conducted on all control
animals, all animals in the highest dose group with at least
60 % survivors at study termination, and all aninmals in
higher dose groups inclusive of early deaths. The following
organs and/or tissues were included in complete
histopathological examinations, as well as any tissue
masses, gross lesions, and associated regional lymph nodes:
adrenals, aorta, bone (sternebrae, femur, or vertebrae,
including marrow), brain, bronchi, clitoral gland,
epididymis, oesophagus, heart, kidney, large intestines
(caecum, colon,rectum), liver, lungs, lymph nodes
(mesenteric), mammary glands, nasal cavity and turbinates,
oral cavity, ovaries, pancreas, parathyroids, pharynx,
pituitary, preputial gland, prostate, salivary glands,
scrotal sac, seminal vesicles, skin, small intestine
(duodenum, ileum, jejunum), spleen, stomach, testes, thymus,
thyroid, tongue, trachea, tunica vaginalis, urinary bladder,
uterus and Zymbal's glands. For lower level dose groups, all
gross lesions and the following target organs were examined
histopathologically: bone marrow, nasal mucosa, thyroid
gland, uterus. Organ weights recorded for brain, liver,
right kidney, thymus, heart, and lungs of all animals, and
the right testis of all males.
HAEMATOLOGIC, CLINICAL CHEMISTRY, and URINALYSIS
determinations included.
haematocrit, haemoglobin, red blood cell count, mean cell
volume (only females), meam cell haemoglobin, mean cell
haemoglobin concentration (only females), platelets,
reticulocytes, white blood cell count, lymphocytes,
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