m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Vehicle :
Doses :
Method : other
Year :
GLP : no data
Test substance : other TS: 96-98% pure
Remark : p-Cresol was administered as a 20% aqueous emulsion to
non-fasted albino rabbits by stomach tube to give doses of
280-1400 mg/kg bw and the time until death was monitored.
According to the methods section, equal numbers of males and females
were employed and, in the results section, one
animal/dose was tested. Presumably this is one
rabbit/sex/dose but this is unclear in the report. The
total observation period was not reported.
Signs and symptoms of poisoning were similar to those
caused by phenol which included muscle twitching,
temperature and pulse and respiratory rate fluctuations,
salivation, convulsions, lethargy and coma. Animals
survived doses of up to 420 mg/kg bw and the times until
death at doses of 620, 940 and 1400 mg/kg bw were 4, 12 and
2hr respectively.
Reliability : (4) not assignable
documentation insufficient for assessment
06.01.2003 (136)
Type : LD50
Value : = 207 mg/kg bw
Species : rat
Strain : no data
Sex : male
Number of animals : 5
Vehicle : other: none
Doses : 100, 147, 215, 316 mg/kg bw
Method : other: 5 rats/dose group, 4 doses, undiluted liquid, time of recovery: up to
14 d
Year : 1969
GLP : no data
Test substance : other TS: p-cresol, M.P.: 36 C; B.P.: 202 C
Remark : Doses and mortality:
100 mg/kg bw: 0/5; 147 mg/kg bw: 0/5; 215 mg/kg bw: 3/5; 316
mg/kg bw: 5/5
Signs of intoxication: hypoactivity, tremors, lacrimation,
dyspnea, hemorrhagic rhinitis, convulsions, prostration,
death
Necropsy of the rats that died revealed gastrointestinal
inflammation and haemorrhage and hyperaemia of the lungs,
liver and kidney.
Survivors showed only gastrointestinal tract inflammation.
Reliability : (2) valid with restrictions
No information about strain used, GLP
Flag : Critical study for SIDS endpoint
06.02.2004 (139)
5.1.2 ACUTE INHALATION TOXICITY
256
Type : LC50
Value : > .71 mg/l
Species : rat
UNEP PUBLICATIONS