m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
summary: irritation score: 87.3/110
Reliability : (2) valid with restrictions
observation time should be longer to evaluate reversibility
Flag : Critical study for SIDS endpoint
06.02.2004 (116)
Species : rabbit
Concentration : other: see method
Dose :
Exposure time : unspecified
Comment :
Number of animals :
Vehicle :
Result : highly irritating
Classification :
Method : other: instillation of a 5 % solution and a 1 % solution, solvent: propylene
glycol
Year : 1949
GLP : no
Test substance : other TS: no data on purity
Remark : 5 % solution: severe damage of the cornea
1.0 % solution: was harmless
result: Grade 9/10
Reliability : (4) not assignable
documentation insufficient for assessment
18.09.2002 (120)
5.3 SENSITIZATION
5.4 REPEATED DOSE TOXICITY
Type : Sub-acute
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : inhalation
Exposure period : 2 weeks (14 exposures)
Frequency of treatm. : 6 hrs/d, 7 d
Post exposure period : 2 weeks
Doses : target conc.: 20 ug/l of an 0.25 % solution in 1.6 % aquous glycerol
Control group : other: yes, water
Method : other: see freetext ME
Year : 2001
GLP : yes
Test substance : other TS: m-cresol, not specified further
Method : 6 rats/sex /group, nose-only exposure to an aerosol, target conc. 20 ug/l,
target pulmonary dose: 504 ug/kg bw/day
observations for mortality, moribundity twice daily during exposure and
during recovery, clinical observations (hematology, blood chemistry) within
one hour of exposure during exposure and during recovery period, record
of body weight prior to first exposure and weekly during exposure and
during recovery period,
complete necropsy was performed on all animals at completion of
exposure and recovery period including external and internal examination:
body orifices, body cavities, external and cut surfaces, record of organ
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