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OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 as the only parameter affected (adjusted live pup weight) was decreased if either sex was dosed. F1-pups: 1.5 %-group: birth weights decreased by 5 %, decreased preweaning growth by 26 % and postweaning survival decreased by 39 % clinical signs: reduced size, dehydratation, lethargy, rough coat F1-adults: no effect on reproductive performance: 1.0 and 1.5%-group, male: decreased bw, decreased reproductive organ weights (prostate, seminal vesicles, testes), but no effects on sperm parameters or histology, increased relative liver and kidney weights 1 and 1.5 %-group, female: terminal bw reduced 0.25-, 1.0-, and 1.5 %-group, female: ovarian weight reduced, kidney- and liver-weights increased no effect of treatment on oestrous cyclicity and ovarian or liver and kidney histology NOAEL(F0, F1, general toxicity): 0.25 %, based on differences in bw and organ weights to the concurrent controls. Reproductive competence of F0, F1-generation was not affected by treatment. NOAEL(fertility, F0, F1): 1 % F0-generation 1.5 % - group: decreased adjusted live pups weights, decreased number of live pups per litter and increase of the cumulative days to the fifth litter F1 generation 1.5 % -group: live pup weights and adjusted live pup weights reduced. Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 05.02.2004 (102) 5.8.2 DEVELOPMENTAL TOXICITY/TERATOGENICITY 19.06.2002 5.8.3 TOXICITY TO REPRODUCTION, OTHER STUDIES Type : other: In vitro/in vivo : In vivo Species : rat Sex : male/female Strain : other: F344/N Route of admin. : oral feed Exposure period : 13 w Frequency of treatm. : daily Duration of test : 13 w Doses : 0, 1880, 7500, 30000 ppm Control group : yes, concurrent no treatment Result : See freetext RS 366 UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 Method : other: determination of sperm motility and concentration in males and length of oestrus cycle and vaginal cytology following repeated dose according EPA OPP 82-1 Year : 1991 GLP : yes Test substance : other TS: m-/p-cresol (60%:40% mixture) Remark : see also chapter 5.4. Result : males: no difference to the respective controls in weights of right testicle, right epididymis, right epididymal tail, no difference in the concentration of viable sperm, only slight but sign. reduced sperm motility at 30000 ppm females: increased oestrus cycle length from 7500 ppm Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 16.12.2002 (101) Type : other In vitro/in vivo : In vivo Species : mouse Sex : male/female Strain : B6C3F1 Route of admin. : oral feed Exposure period : 13 w Frequency of treatm. : daily Duration of test : 13 w Doses : 0, 625, 2500, 10000 ppm Control group : yes, concurrent no treatment Result : No findings Method : other: determination of sperm motility and concentration in males and length of oestrus cycle and vaginal cytology following repeated dose according EPA OPP 82-1 Year : 1991 GLP : yes Test substance : other TS: m-/p-cresol (60%:40% mixture) Remark : see also chapter 5.4. Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 18.06.2002 (101) Type : other In vitro/in vivo : In vivo Species : rat Sex : male/female Strain : other: F344/N Route of admin. : oral feed Exposure period : 28 d Frequency of treatm. : continuously in feed Duration of test : 28 d Doses : 0, 300, 1000, 3000, 10000, 30000 ppm (m: 0, 26, 90, 261, 877, 2600 mg/kg bw; f: 0, 27, 95, 268, 886, 2570 mg/kg bw) Control group : yes, concurrent no treatment Result : male, 30000 ppm: increased right testes weight without histopathologic correlate Method : other: description in chapter 5.4 Year : 1991 GLP : yes Test substance : other TS: m/p-cresol (60%:40% mixture) UNEP PUBLICATIONS 367
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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