m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
4. ECOTOXICITY ID: 106-44-5
DATE: 24.05.2004
Test substance : other TS: p-cresol, no purity reported
Test condition : - Delivery system: Flow-through test.
- Dilution water: soft water from lake Superior.
- Fluorescent lights provided 16h light per day.
- Water chemistry data was recorded at the Environmental Research
Laboratory, Duluth, MN. Recorded data can be required.
- The test was begann with the egg-stage.
- Fish were fed newly hatched brine shrimp ad libitum twice per day so that
moderate accumulation occured.
- Statistical analysis: effect on growth was examined by log-linear doseresponse
analysis; there was a control and five treatments with two
replicates.The lowest effect concentration was determined by Dunnetts
multiple range test. Regression analysis was performed.
- Endpoint: effect on larval growth by measuring lenght or weight
Reliability : (2) valid with restrictions
Test procedure comparable to standard method and in
accordance with generally accepted scientific standards;
water chemistry data not reported
Flag : Critical study for SIDS endpoint
07.05.2004 (82)
4.5.2 CHRONIC TOXICITY TO AQUATIC INVERTEBRATES
Species : Daphnia magna (Crustacea)
Endpoint : Mortality
Exposure period : 21 day(s)
Unit : mg/l
NOEC : 1
Analytical monitoring : Yes
Method : other: preliminary guideline proposal of the German Umweltbundesamt,
state 1984-01-01
Year : 1988
GLP : no data
Test substance : other TS: p-cresol, no purity reported
Method : Determination of NOEC for reproduction rate, mortality and the time of the
first appearance of offspring; 21d
Remark : - Only the ominal value for the most sensitive parameter is given. However
no losses were reported to be greater than 20%.
- Tested concentration range: 0.003-10 mg/l.
- Most sensitive parameter was mortality:
NOEC-nominal value = 1 mg/l
Test condition : TEST ORGANISMS
- Strain: IRCHA strain
- Age: 24 h
DILUTION WATER
- Source: synthetic fresh water
- Hardness: 2.5 mmol/l Ca + Mg
- Na/K ratio: 10:1
- pH: 8.0 +- 0.2
TEST SYSTEM
- semistatic system
- Number of replicates: 4
- individuals per replicate: 20
- Test temperature: 25 +- 1 degrees C
244
H-values and oxygen-concentration were measured during the test in two
tests-vessels per concentration level.The detected variation of these
parameters had no negative influence on the organism.
UNEP PUBLICATIONS