m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Remark : In humans, m-cresol may be excreted as a metabolite in urine
after occupational exposure to phenols, cresols, xylenols,
naphthalene and/or toluene.
Reliability : (4) not assignable
14.01.2003 (165) (166) (167) (168) (169) (170) (171)
Remark : The probable oral lethal dose for humans is 50-500 mg/kg.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
14.01.2003 (172)
Remark : In humans, insulin preparations with m-cresol resulted in an
impaired leukocyte function (decreased killing capacity of
human polymorphonuclear leukocytes (PMNL), expressed as the
percentage of Staphylococcus aureus killed after 60 minutes
of incubation). m-cresol is possibly implicated in the
pathogenesis of local infections in continuous subcutaneous
insulin infusion
Reliability : (4) not assignable
15.01.2003 (173)
Remark : Case report: A 44-y-old male was found unconscious after
ingestion of 300 ml of 50 % cresol-soap solution.
Endotracheal intubation, gastric lavage and activated
charcoal reversed his conscious. He had dermal burns,
oesophageal and gastric erosions, pneumonia, mixed metabolic
acidosis and respiratory alkalosis, renal and liver function
impairment, leucocytosis and dark urine. Acute renal failure
and hemolysis developed, but recovered after hemodialysis
and intensive supportive care.
Urine levels of p-,m-,o-cresol and phenol were resp. 2083,
2059, 125 and 68 mg/g creatinine at 7 h post ingestion.
The patient recovered.
Reliability : (4) not assignable
15.01.2003 (174)
Remark : case report: Accidental dermal exposure of both legs and face of a 47-
year-old man resulted in corrosion of 15 % of his body surface and he
developed acute polyuric renal failure. Serum levels of m-cresol after 1 h
were above 30 mg/l.
After 5 hemodialysis procedures renal function recovered.
Levels of m-cresol in the dialysate were less than 5 % of
the levels in serum. Hemodialysis had no significant effect
on the serum concentration time course of m-cresol.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
14.01.2003 (175)
Remark : The Agency for Toxic Substances and Disease Registry (ATSDR)
Minimal Risk Levels (MLR) were developed to provide
screening levels for health assessors and other responders
to identify contaminants and potential health effects that
may be of concern at hazardous waste sites an releases. An
MRL is an estimate of the daily human exposure to a
hazardous substance that is likely to be without
appreciable risk of adverse noncancer health effects over a
UNEP PUBLICATIONS 157