m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
4. ECOTOXICITY ID: 106-44-5
DATE: 24.05.2004
4.1 ACUTE/PROLONGED TOXICITY TO FISH
222
Type : flow through
Species : Pimephales promelas (Fish, fresh water)
Exposure period : 96 hour(s)
Unit : mg/l
LC50 : = 16.5
EC50 : = 16.5
Limit test :
Analytical monitoring : yes
Method : other
Year : 1985
GLP : no
Test substance : other TS: p-cresol, purity at least 99 % (Aldrich Chemical Co.)
Method : Fish (28 d old; mean lenght: 20.9 mm; mean weight: 0.134 g)
exposed in Lake Superior water; 5 TS concentrations in the
range of 11.8 to 66.2 mg/l tested (plus control); number of
dead fish recorded every 24 h; observations of fish
behaviour and body morphology at regular intervals; TS
analysis by GLC
Result : confidence limits (95%):
LC50 = EC50 = 15.9 - 17.0 mg/l
Affected fish lost schooling behaviour and swam near the
tank surface. They were hyperactive and overreactive to
external stimuli. They had increased respiration,
convulsions, and rigid musculature. Some hemorrhaging was
also apparent. They were deformed and lost equilibrium prior
to death.
Test condition : 24.1 degrees C; dissolved oxygen 7.0 mg/l; hardness 47.9 mg
CaCO3/l; alkalinity 44.1 mg CaCO3/l; pH 7.79
Reliability : (1) valid without restriction
Test procedure comparable to standard method and in
accordance with generally accepted scientific standards;
detailed documentation of test procedure and test conditions
Flag : Critical study for SIDS endpoint
07.05.2004 (78)
Type : flow through
Species : Oncorhynchus mykiss (Fish, fresh water)
Exposure period : 96 hour(s)
Unit : mg/l
LC50 : = 7.9
Limit test :
Analytical monitoring : yes
Method : EPA OPP 72-1
Year : 1974
GLP : no data
Test substance : other TS: p-cresol, purity not noted
Remark : lethargic at 5.6 mg/l
Test condition : DILUTION WATER
- Source: well water
- Hardness: 707.3 mg CaCO3/l
- Conductance: 1212.3 µmhos/cm at 25 degrees C
TEST SYSTEM
- Concentrations: 1:2 dilution series
- Number of replicates: 2
- fish per replicate: 10
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