m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
p-Cresol
p-Cresol inhibited both UV-induced DNA repair synthesis and semiconservative DNA synthesis as
evidenced by a reduction in radiolabelled thymidine incorporation (Daugherty and Frank 1986).
Induction of UDS was reported in Human Lung fibroblasts (Crowley and Margard 1978).
In vitro activation of p-cresol with either horseradish peroxidase or PB-induced rat liver
microsomes followed by incubation with calf-thymus DNA resulted in DNA adducts which are the
same as that produced by the quinone methide of p-cresol (Gaikwad and Bodell 2001).
m/p-Cresol
There are no data available using a m/p-cresol mixture.
Conclusion:
In vitro, p-cresol may induce unscheduled DNA synthesis, and the in vitro metabolite quinone
methide can form DNA adducts. Contradictory results for UDS induction were reported with m-
cresol from two studies both suffering from deficiencies. Thus, it is possible that m- and p-cresol
and m/p-cresol mixtures have the potential to interact with DNA either directly or indirectly via
metabolites.
in vivo
(A) Gene mutation
m-Cresol
There are no data available
p-Cresol
A Drosophila melanogaster SLRL test was negative following oral feeding of adult males with 0,
60, 300 or 600 µg/ml for three days (Hazleton Lab. Am. 1989).
m/p-Cresol
There are no data available using a m/p-cresol mixture.
Conclusion
p-Cresol did not induce gene mutations in Drosophila melanogaster.
(B) Cytogenicity
m-Cresol:
There is a study on cytogenicity (chromosome aberration) in 5 mice/sex/group following single oral
application by gavage (0, 96, 320 and 960 mg/kg bw in corn oil) according to OECD guideline 475.
Signs of toxicity were observed for the two highest dose groups and included scruffy coats, squinty
eyes and difficulties in breathing. 3 male mice of the 960 mg-group were found dead during the
study observation. m-Cresol revealed no clastogenic activity in bone marrow cells (Hazleton Lab.
Am. 1988d).
p-Cresol
To determine the potential of p-cresol to induce dominant lethal mutations in germ cells male mice
received single oral doses by gavage of 0, 100, 275 or 650 mg/kg bw suspended in corn oil.
Because of the excessive toxicity within the first week after dosing high dose animals were
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