m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
Table 5:
m-Cresol: Repeated Dose Toxicity Rat/Mouse
Study-Description NOAEL Effects Reference
Rat
5 rats/sex/dose, 28 d, feeding
0, 300, 1000, 3000, 10,000,
30,000 ppm
(m: 0, 25, 85, 252, 870, 2470
mg/kg bw/day;
f: 0, 25, 82,252, 862, 2310
mg/kg bw/day),
30 rats/sex/dose, 13 w gavage
0, 50, 150, 450 mg/kg bw/day in
corn oil
10 rats/sex/dose, 13 w gavage
20 rats/sex as control
0, 50, 150, 450 mg/kg bw/day
in corn oil
neurotoxicity study
available as summary only
Mouse
5 mice/sex/dose, 28 d feeding
0, 300, 1000, 3000, 10,000,
30,000 ppm
(m: 0, 53, 193, 521,1730, 4710
mg/kg bw;
f: 0, 66, 210, 651, 2080, 4940
mg/kg bw)
3000 ppm
(252
mg/kg
bw/day)
Males: 50
mg/kg
bw/day
Females:
150
mg/kg
bw/day
No mortality, no clinical signs of toxicity
30,000 ppm, m, f: decreased body weight gain and
final body weight, decreased food consumption,
minimal to mild uterine atrophy in 4/5 females; no
histopathological changes in other organs
≥ 10,000 ppm: increased rel liver weights
450 mg: 1 male died (gavage error), lethargy, tremor,
hunched posture, dyspnoe, reduced body weight gain,
decreased food consumption (m); no histopathological
changes
150 mg: reduced bw gain (m)
* 450 mg: reduced food consumption (m,f) convulsions,
death of 1 female, urination ↑ (f)
1000 ppm
(m: 193
mg/kg
bw/day),
< 300
ppm (f, 66
mg/kg
bw/day)
≥ 50 mg: clinical signs as salivation, urine wet
abdomen, hypoactivity, rapid and labored respiration,
myoclonus, hyperreactivity
Mortality: 1/5 control male; 30,000 ppm: 2/5 f, 2/5 m;
10,000 ppm: 1/5 f
30,000 ppm, m,f: reduced body weight gain, and final
body weight, decreased food consumption, thin
appearance, lethargy, tremor, hypothermia (f only), in
females atrophy of mammary gland, ovaries, uterus;
no histopathological changes in liver and kidneys
NTP 1991
Microbiolo
gical
Associates
Inc 1988a
TRL 1986
NTP 1991
≥ 10,000 ppm, m,f: hunched posture, rough hair coat,
laboured breathing(only f)
≥ 3000 ppm: increased rel liver weight (m)
≥ 300 ppm: increased rel liver weight (f)
* due to limitations in the study documentation, NOAELs were not derived
UNEP PUBLICATIONS 21