m-Cresol - ipcs inchem

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OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 Frequency of treatm. : daily Post exposure period : 2 months Doses : 0.01 mg/l Control group : no data specified LOAEL : = .01 mg/l Method : other Year : GLP : no data Test substance : other TS: p-cresol, purity not noted Remark : Females were exposed to p-cresol aerosols. The original data are unpublished and no further experimental details are available from the citing review (IPCS, 1993). Result : Clinical signs of toxicity included loss of appetite, marked emaciation and decreased locomotor activity. Irritative effects, which persisted throughout recovery, were seen on the nose, eye and skin. Decreased body weight gain and lung weight, increased liver weight, oliguria and dystrophic changes in the lung and liver occurred. Throughout recovery the body weights remained depressed and urinary excretion remained low. Reliability : (4) not assignable secondary literature: experimental details are missing, only one dose used 15.10.2002 (125) Type : Species : mouse Sex : female Strain : CBA Route of admin. : dermal Exposure period : 6 weeks Frequency of treatm. : 3x/week Post exposure period : 6 months Doses : 0 or 0.5 % in acetone Control group : yes, concurrent vehicle NOAEL : < .5 % LOAEL :
OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 Post exposure period : 6 months Doses : 0.5 % in acetone Control group : no data specified NOAEL : < .5 % LOAEL : 97% Method : S-9 FRACTION: liver fractions were prepared from male Sprague-Dawley rats and male Syrian hamsters that were injected with Arcolor 1254; POSITIVE CONTROLS: 2-aminoanthracene, 4-nitro-o-phenylenediamine, sodium acide 9-aminoacridine; SOLVENT: water, POSITIVE RESPONSE: was indicated by a reproducable, dose-related increase wether it be two-fold over background or not STATISTICAL METHODS: analysis based on the models presented by Margolin Result : Positive controls were functional Reliability : (2) valid with restrictions only 4 strains of Salmonella typhimurium were used Flag : Critical study for SIDS endpoint 06.02.2004 (153) Type : Cytogenetic assay System of testing : Chinese hamster ovary cells UNEP PUBLICATIONS 269
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS m-CRESOL 6. REFERENCES ID
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OECD SIDS p-CRESOL 1. GENERAL INFOR
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m-Cresol - ipcs inchem

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