m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Method : other: exposure to saturated vapour produced at room temperature by
bubbling air at 2.5 l/min, observation period 14 d
Year : 1949
GLP : no
Test substance : other TS: m-cresol, not specified further
Remark : m-Cresol did not affect rats in 8 h exposure periods, all of the rats gained
weight during the observation period
Reliability : (2) valid with restrictions
description considered of sufficient quality to allow evaluation
Flag : Critical study for SIDS endpoint
06.02.2004 (120)
5.1.3 ACUTE DERMAL TOXICITY
Type : LD50
Value : = 1100 mg/kg bw
Species : rat
Strain :
Sex : no data
Number of animals :
Vehicle : no data
Doses :
Method : other: no data
Year : 1974
GLP : no data
Test substance : other TS: no data
Reliability : (4) not assignable
secondary citation
17.12.2002 (112) (119)
Type : LD50
Value : = 2050 mg/kg bw
Species : rabbit
Strain : no data
Sex : no data
Number of animals : 5
Vehicle : other: none
Doses : 1000, 1470, 2150, 3160 mg/kg bw
Method : other: 5 rabbits/dose, 4 doses, exposure time not mentioned, up to 14 days
post exposure observation time
Year : 1969
GLP : no data
Test substance : other TS: m-cresol, M.P.: 11-12 C; B.P.: 202.8 C
Result : Dosage onset of symp. mortality mortality
mg/kg 4-12 hrs 12-24 hrs day3 cumulative
1000 0/5
1470 0/5
2150 S 4/5 4/5
3160 S 4/5 4/5
S = signs of intoxication from 4 hrs up to 12 hrs p.a.:
lacrimation, salivation,
hypersensitivity, convulsion, hypoactivity:
dermal
irritation: severely burned, severe edema
126
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