m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Method : The method used was essentially that of Smyth et al. 1962 (Am. Ind. Hyg.
Ass. J. 23, 95-107) except three females/dose were tested 24 hr occlusive
exposure to the neat material was followed by a 14-day observation period.
the most probable LD50 value was determined by the method of
Thompson 1947 (Bact. Rev.11, 115-145)of moving averages. Clinical signs
and purity of the Ts are not reported.
Reliability : (2) valid with restrictions
no guideline study: clinical signs and purity of Ts are not reported
Flag : Critical study for SIDS endpoint
06.02.2004 (140)
Type : LD50
Value : = 750 mg/kg bw
Species : rat
Strain :
Sex :
Number of animals :
Vehicle :
Doses :
Method : other
Year :
GLP : no data
Test substance : other TS: p-cresol, purity not noted
Remark : The dermal LD50 value was measured in rats. No further experimental
details are available from the citing reference (IPCS, 1995).
Reliability : (4) not assignable
secondary citation
13.12.2002 (129) (138) (141)
Type : LD50
Value : ca. 300 mg/kg bw
Species : rabbit
Strain : no data
Sex : no data
Number of animals : 5
Vehicle : other: none
Doses :
Method : other: 5 rabbits/dose, 4 doses, exposure time not mentioned, up to 14 d
observation time, gross autopsy
Year : 1969
GLP : no
Test substance : other TS: p-cresol, purity not noted; M.P.: 36 C; B.P.: 202 C
Remark : doses and mortality:
215mg/kg bw: 1/5; 316 mg/kg bw: 3/5; 464 mg/Kg bw: 4/5; 681
mg/kg bw: 5/5
signs of intoxication from 4-12 hrs post appl.: tremor,
salivation sedation, death
dermal irritation: severe subdermal hemorrhaging, severe
erythema
gross autopsy: survivors: no significant findings;
decedents:
inflammation of kidneys
Reliability : (2) valid with restrictions
no information about strain used and no information on GLP
Flag : Critical study for SIDS endpoint
06.02.2004 (139)
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