m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
I. method: initiator: single dermal appl. of 0.3 % DMBA in acetone;
m-cresol was applied as promotor to the back of each mouse
I. result: 14/29 mice (12/12 benzene control animals)
survived and in 50 % (0 % in control animals)
skin papillomas were found; no carcinomas were
detected
II.method: initiator: 0.3 % DMBA in benzene;
promotor: m-cresol was applied to the back of
each mouse
II.result: 17/20 mice (18/20 benzene control animals)
survived and in 24 % (0 % in control animals)
skin papillomas were found; no carcinomas were
detected
Result : m-cresol was evaluated as promotor
Reliability : (2) valid with restrictions
no data on purity, benzene a known carcinogen as solvent, high mortality
rate
Flag : Critical study for SIDS endpoint
06.02.2004 (151)
Species : other: in vitro cell transformation assay
Sex :
Strain : other: mouse BALB/c-3T3 cells
Route of admin. :
Exposure period :
Frequency of treatm. :
Post exposure period :
Doses : 0.57 - 48 nl/ml culture medium
Result : negative
Control group : yes
Method : other: see freetext ME
Year : 1988
GLP : yes
Test substance : other TS: m-cresol, purity > 99 %
Method : 40CFR 795.285 (modified), preliminary clonal cytotoxicity test, performance
of the test according to Kakunaga, Int. J. Cancer 12, 463, 1973, without
metabolic activation, negative and positive controls
Result : Meta-cresol did not induce cell transformation in this assay; cytotoxicity: 48
nl/ml
Reliability : (2) valid with restrictions
non-validated test system
Flag : Critical study for SIDS endpoint
06.02.2004 (152)
Species : other: in vitro cell transformation assay
Sex :
Strain : other: mouse BALB/c-3T3 cell
Route of admin. :
Exposure period :
Frequency of treatm. :
Post exposure period :
Doses : 6 - 72 nl/ml culture medium
Result : negative
Control group : yes
Method : other: preliminary cytotoxicity test, performance of the test according to
Kakunaga, Int. J. Cancer 12, 463, 1973, with metabolic activation
Year : 1988
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