m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
and liver.
Microscopic changes which were characterized by average
severity score based on scale of 1 to 4 (1=minimal, 2=mild,
3=moderate, 4=marked) were reported from
nose (contr., low dose to high dose, respiratory epithelium
hyperplasia: male, 0/5, 300 and 1000 ppm: not performed,
0/5, 1/5[1.0], 5/5[1.6]; female, 2/5[1.5], low dose: not
performed, 0/5, 3/5[1.0], 3/5[1.7], 4/5[1.5]; olfactorium
epithelium: at 30000 ppm, male, atrophy 2/5[1.0] and
respiratory metaplasia 3/5 [1.3]; female, olfactory
epithelium respiratory metaplasia at 30000 ppm, 2/5[1.0]),
lung (bronchiolar hyperplasia, minimal in males and females
at 30000 ppm),
oesophagus (males, minimum hyperplasia and hyperkeratosis at
30000 ppm),
forestomach (males, at 30000 ppm, minimal hyperplasia of the
squamous epithelium),
bone marrow (minimal hypocellularity at 30000 ppm),
atrophy of the ovary (mild) and uterus (moderate) at 30000
ppm
local toxicity:
NOAEL(male): 3000 ppm; NOAEL(female): 1000 ppm systemic
toxicity:
NOAEL(male): 300 ppm; NOAEL(female): 1000 ppm
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
05.02.2004 (101)
Type : Sub-acute
Species : mouse
Sex : male/female
Strain : CD-1
Route of admin. : oral feed
Exposure period : 14 d
Frequency of treatm. : daily
Post exposure period : no
Doses : 0, 0.25, 0.5, 1.0, 1.5, 2.0, 3.0 % (target dose: 0, 375, 750, 1500, 2250,
3000, 4500 mg/kg bw)
Control group : yes, concurrent no treatment
Method : other: NTP continuous breeding protocol, task 1 see freetext ME
Year : 1990
GLP : yes
Test substance : other TS: m-/p-cresol (60%/40%)
Method : 48 male and 48 female mice: 8 per sex per dose, data
collected included clinical signs, individual body weights,
feed and water consumption, mortality data
Result : mortality:
3.0 %-gr.: 1/8 (12.5 %) males, 1/8 (12.5 %) females (due to
indeterminant causes)
Clinical signs:
all mice in 3.0 %-, and some in 2.0 %- and 1.0 %-group:
lethargy, hunched back, squinted eyes, rough coat
dose related reduced feed consumption, water consumption and
reduced body weight gain
3 %-group: sign. terminal weight loss of males and females
Reliability : (2) valid with restrictions
preliminary dose range finding study for the two generation
reproductive study: see also chapter 5.8.1
04.09.2002 (102)
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