m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Strain : no data
Sex : male
Number of animals : 6
Vehicle : other: air
Doses :
Exposure time : 1 hour(s)
Method : other: 6 rats exposed to 0.71 mg/l for 1 hr, room temperature, up to 14 d
post exposure observation, gross necropsy
Year : 1969
GLP : no
Test substance : other TS: p-cresol, purity not noted, M.P.:36 C, B.P.: 202 C
Result : Mortality: 0/6; signs of intoxication: none; gross autopsy: no significant
findings
Reliability : (2) valid with restrictions
no guideline study: 1 hr exposure time
Flag : Critical study for SIDS endpoint
06.02.2004 (139)
Type : other
Value : = .029 mg/l
Species : rat
Strain :
Sex :
Number of animals :
Vehicle :
Doses :
Exposure time :
Method : other: aerosol exdosure; no further data
Year :
GLP : no data
Test substance : other TS: p-cresol, purity not noted
Remark : The mean lethal concentration of p-cresol in rats was
measured. The original data are unpublished and no further
experimental details are available from the citing review
(IPCS, 1993).
Result : Clinical signs of toxicity included irritation of mucous membranes,
neuromuscular excitiation and convulsions; hematuria at very high
concentrations (no further information)
Reliability : (2) valid with restrictions
Secondary citation from peer-reviewed data source
Flag : Critical study for SIDS endpoint
04.02.2004 (125)
5.1.3 ACUTE DERMAL TOXICITY
Type : LD50
Value : = 300 mg/kg bw
Species : rabbit
Strain :
Sex : female
Number of animals : 3
Vehicle : other: undiluted
Doses : 130 - 910 mg/kg bw
Method : other: see freetext ME
Year : 1977
GLP : no data
Test substance : other TS: p-cresol, not specified further
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