m-Cresol - ipcs inchem

More documents

Recommendations

Info

OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 NEGATIVE CONTROL: 0.35 ml sunflower oil (4 intact and 5 hepatectomized male mice, bone marrow cells, alveolar macrophages, liver cells) POSITIVE CONTROL: 5 mg cyclophosphamide/kg bw (2 intact male mice, bone marrow cells, alveolar macrophages). STATISTICAL ANALYSIS: One way analysis of variance; Dunnett's test for comparison Result : p-<strong>Cresol</strong> did not induce significant increases in SCE frequencies in any of the cell types examined: bone marrow cells, alveolar macrophages, liver cells. The dose tested was overtly toxic to the mice, causing lethargy, piloerection and lacrimation. The positive control was functional. Reliability : (2) valid with restrictions only one dose tested, no information on GLP Flag : Critical study for SIDS endpoint 06.02.2004 (159) 5.7 CARCINOGENICITY 276 Species : mouse Sex : female Strain : other: Sutter Route of admin. : dermal Exposure period : 12 weeks (I) or 20 weeks (II) Frequency of treatm. : twice weekly Post exposure period : no Doses : 20 (I) or 5.7 % (II) solutions in benzene Result : Control group : yes, concurrent vehicle Method : other: tumor promotion test (see freetext RM) Year : 1959 GLP : no Test substance : other TS: p-cresol, not specified further Remark : Groups of 20-29 Sutter strain mice: I. method: initiator: single dermal appl. of 0.3 % 9,10-dimethyl-1,2- benzanthracene (DMBA) in acetone; p-cresol (in benzene) was applied as promotor to the back of each mouse I. result: 20/28 mice (12/12 benzene control animals); survived and in 35 % (0 % in control animals); skin papillomas were found; no carcinomas were detected II. method: initiator: single dermal appl. of 0.3 % DMBA in benzene; promotor: p-cresol was applied to the back of each mouse II.result: 14/20 mice (18/20 benzene control animals) survived and in 29 % (0 % in control animals) skin papillomas were found; no carcinomas were detected Result : p-<strong>Cresol</strong> was evaluated as promotor Reliability : (2) valid with restrictions no data on the purity, benzene a known carcinogen as solvent, high mortality rate; no information on skin irritation effects Flag : Critical study for SIDS endpoint 06.02.2004 (165) Species : hamster Sex : male Strain : other: Syrian Golden Route of admin. : oral feed Exposure period : 20 weeks UNEP PUBLICATIONS
OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 Frequency of treatm. : daily Post exposure period : no Doses : 0 or 1.5 % in diet (corresponding to about 1100 mg/kg bw/d) Result : Control group : yes, concurrent no treatment Method : other: 15 males/group, Year : 1986 GLP : no data Test substance : other TS: >98% pure. Result : An increased incidence of mild to moderate forestomach hyperplasia occurred (10 animals: moderate; 5 animals: mild) when compared with the controls. Marked hyperplasia or papillomatous lesions were not observed. Reliability : (2) valid with restrictions limited documentation; small number of animals; limited scope of examinations; short exposure 16.12.2002 (166) Species : other: in vitro cell transformation assay Sex : Strain : other: mouse BALB/c-3T3 cells Route of admin. : Exposure period : Frequency of treatm. : Post exposure period : Doses : 0.81, 3.25, 5, 10, 15 nl/ml culture medium Result : positive Control group : other: yes, neg control: culture medium with 10 %FCS; pos. control: 3- methylcholanthrene Method : other: 40CFR 795.285 (modified); preliminary cytotoxicity test, performance of the test according Kakunaga, Int. J.Cancer 12,463,1973, without metabolic activation Year : 1988 GLP : yes Test substance : other TS: p-cresol, purity: 99.8 % Result : p-cresol produced a dose-related increase in the number of foci/plate over the entire concentration range. The test material induced cell transformation that was significantly elevated when compared to the controls. Test material toxicity was determined in priliminary assays Reliability : (2) valid with restrictions non-validated test system Flag : Critical study for SIDS endpoint 06.02.2004 (167) 5.8.1 TOXICITY TO FERTILITY Type : Two generation study Species : rat Sex : male/female Strain : Sprague-Dawley Route of admin. : gavage Exposure period : see remarks Frequency of treatm. : 5 days per week Premating exposure period Male : 10 weeks Female : 10 weeks Duration of test : see remarks UNEP PUBLICATIONS 277
Page 1 and 2:
OECD SIDS m- / p-CRESOL FOREOWRD IN
Page 3 and 4:
OECD SIDS m- / p-CRESOL 11. Comment
Page 5 and 6:
OECD SIDS m- / p-CRESOL of mice. In
Page 7 and 8:
OECD SIDS m- / p-CRESOL SIDS Initia
Page 9 and 10:
OECD SIDS m- / p-CRESOL Table 3: Es
Page 11 and 12:
OECD SIDS m- / p-CRESOL m-cresol an
Page 13 and 14:
OECD SIDS m- / p-CRESOL extensive s
Page 15 and 16:
OECD SIDS m- / p-CRESOL et al. 1993
Page 17 and 18:
OECD SIDS m- / p-CRESOL study in wh
Page 19 and 20:
OECD SIDS m- / p-CRESOL Conclusion:
Page 21 and 22:
OECD SIDS m- / p-CRESOL Table 5: m-
Page 23 and 24:
OECD SIDS m- / p-CRESOL ≥300 ppm,
Page 25 and 26:
OECD SIDS m- / p-CRESOL Atrophy and
Page 27 and 28:
OECD SIDS m- / p-CRESOL p-Cresol p-
Page 29 and 30:
OECD SIDS m- / p-CRESOL 3.1.7 Carci
Page 31 and 32:
OECD SIDS m- / p-CRESOL weights wer
Page 33 and 34:
OECD SIDS m- / p-CRESOL drowsiness,
Page 35 and 36:
OECD SIDS m- / p-CRESOL and reduced
Page 37 and 38:
OECD SIDS m- / p-CRESOL The most se
Page 39 and 40:
OECD SIDS m- / p-CRESOL Table 14: T
Page 41 and 42:
OECD SIDS m- / p-CRESOL Table 15: T
Page 43 and 44:
OECD SIDS m- / p-CRESOL 5 RECOMMEND
Page 45 and 46:
OECD SIDS m- / p-CRESOL BRRC (Bushy
Page 47 and 48:
OECD SIDS m- / p-CRESOL Hamster Ova
Page 49 and 50:
OECD SIDS m- / p-CRESOL Nobel W, Ma
Page 51 and 52:
OECD SIDS m- / p-CRESOL Vernot EH,
Page 53 and 54:
OECD SIDS m- / p-CRESOL Available P
Page 55 and 56:
OECD SIDS m- / p-CRESOL √ informa
Page 57 and 58:
OECD SIDS m-CRESOL 1. GENERAL INFOR
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
OECD SIDS m-CRESOL 3. ENVIRONMENTAL
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
OECD SIDS m-CRESOL 4. ECOTOXICITY I
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
OECD SIDS m-CRESOL 5. TOXICITY ID:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
OECD SIDS m-CRESOL 6. REFERENCES ID
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
OECD SIDS p-CRESOL 1. GENERAL INFOR
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
OECD SIDS p-CRESOL 2. PHYSICO-CHEMI
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
OECD SIDS p-CRESOL 3. ENVIRONMENTAL
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
OECD SIDS p-CRESOL 4. ECOTOXICITY I
Page 225 and 226: OECD SIDS p-CRESOL 4. ECOTOXICITY I
Page 249 and 250: OECD SIDS p-CRESOL 5. TOXICITY ID:
Page 275: OECD SIDS p-CRESOL 5. TOXICITY ID:
Page 287 and 288: OECD SIDS p-CRESOL 6. REFERENCES ID
Page 295 and 296: OECD SIDS m- / p-CRESOL MIXTURE I U
Page 297 and 298: OECD SIDS m- / p-CRESOL MIXTURE 1.
Page 327 and 328:
OECD SIDS m- / p-CRESOL MIXTURE 4.
Page 329 and 330:
Page 331 and 332:
Page 333 and 334:
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347 and 348:
Page 349 and 350:
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Page 363 and 364:
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
Page 371 and 372:
Page 373 and 374:
Page 375 and 376:
Page 377:
show all

m-Cresol - ipcs inchem

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?