m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Result : Histological evaluation , characterized by average severity score based on
a scale of 1 to 4 (1=minimal, 2=mild, 3=moderate, 4= marked) revealed
effects:
uterine atrophy in 4/5 females at 30000 ppm
Reliability : (1) valid without restriction
10.07.2002 (130)
Type : Other
In vitro/in vivo : In vivo
Species : Mouse
Sex : male/female
Strain : B6C3F1
Route of admin. : oral feed
Exposure period : 28 d
Frequency of treatm. : continuously in diet
Duration of test : 28 d
Doses : 0, 300,1000, 3000, 10000, 30000 ppm
Control group : yes, concurrent no treatment
Result : see freetext RS
Method : other: the reproductive organs were examined as part of the 28 day study,
see chapter 5.4
Year : 1991
GLP : Yes
Test substance : other TS: purity>98 %
Result : Histopathological evaluation, characterized by average severity score
based on a scale of 1 to 4 (1=minimal, 2=mild, 3=moderate, 4=marked),
revealed effects:
30000 ppm: female, moderate mammary gland atrophy, mild ovary atrophy
and moderate uterus atrophy
Reliability : (1) valid without restriction
10.07.2002 (130)
Type : Other
In vitro/in vivo : In vivo
Species : Rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : Gavage
Exposure period : 13 weeks
Frequency of treatm. : Daily
Duration of test : 14 weeks
Doses : 0, 50, 150, 450 mg/kg bw in corn oil
Control group : yes, concurrent vehicle
Result : no effects on reproductive organs were reported, neither in males nor in
females
Method : other: the reproductive organs were examined as part of the 13 week
study, see chapter 5.4
Year : 1986
GLP : Yes
Test substance : other TS: m-cresol, purity: 98.6 %
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (131)
5.9 SPECIFIC INVESTIGATIONS
Endpoint : Neurotoxicity
Study descr. in chapter :
UNEP PUBLICATIONS 155