m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
4% concentration of p-cresol in petrolatum. The
maximization test involves an induction phase of five
consecutive 48-hr covered patch tests, sometimes separated
by 24-hr periods of treatment with a mild irritant,
followed 10-14 days later by a 48-hr challenge patch using
the same concentration (see: Kligman AM (1966) The identification of
contact allergens by human assay. III. The maximization test. A procedure
for screening and rating contact sensitizers, J. invest. Derm. 47, 393)
Result : There were no sensitization reactions in any of the volunteers.
Reliability : (2) valid with restrictions
cited in monograph of a peer-reviewed international journal;
Flag : Critical study for SIDS endpoint
08.01.2003 (148)
Type : other: modified Draize test
Species : guinea pig
Concentration : 1 st : Induction .1 % intracutaneous
2 nd : Challenge 10 % intracutaneous
3 rd : Challenge 10 % other: topical application
Number of animals : 10
Vehicle : no data
Result : not sensitizing
Classification :
Method : other: see freetext ME
Year : 1978
GLP : no data
Test substance : other TS: p-cresol, not specified further
Method : 10 guinea pigs (4 males and 6 females or vice versa). Both flanks of each
guinea pig were shaved, intradermal injections or topical applications were
performed without occlusion.
Primary irritation tests were performed to determine the suitable
concentrations.
METHOD:
Each animal was injected intradermally with 0.1 ml of TS at 2.5 times the
determined injection challenge concentration (ICC) of 0.1 % at 4 sites
which overlie the 2 auxilliary and the 2 inguinal lymph nodes. 14 days later
each animal was challenged intradermally in one flank and topically in the
other with 0.1 ml aliquots of TS at the respective ICC and application
challenge concentration (ACC; 10%). 24 hours later the reactions were
scored. To confirm the result, the procedure was repeated including a
confirmatory challenge with controls.
Reliability : (2) valid with restrictions
small number of animals tested; reactions should have been scored
additionally at 48 hours
Flag : Critical study for SIDS endpoint
06.02.2004 (149)
5.4 REPEATED DOSE TOXICITY
262
Type : Sub-acute
Species : rat
Sex : male/female
Strain : other: Fischer 344/N
Route of admin. : oral feed
Exposure period : 28 days
Frequency of treatm. : continuously in diet
Post exposure period : none
Doses : 0, 300, 1000, 3000, 10000, 30000 ppm (see freetext RM)
Control group : yes, concurrent no treatment
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