m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Males :
Females :
Doses
Males :
Females :
Vehicle :
Route of administration : oral unspecified
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method :
Year :
GLP :
Test substance : other TS: m-cresol, not specified further
Remark : m-Cresol undergoes entero-hepatic circulation when administered orally to
dogs and rabbits.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
06.02.2004 (110) (111)
In Vitro/in vivo : In vivo
Type : Toxicokinetics
Species : other
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle :
Method :
Year :
GLP :
Test substance : other TS: m-cresol, not specified further
Result : At physiological pH, the conjugated metabolites of phenolic compounds are
ionized to a greater extent than the parent compound, which reduces renal
reabsorption and increases elimination with the urine.
In addition to urinary excretion, cresols are excreted in the bile, but the
most part undergoes enterohepatic circulation. There are known species
differences in the specific conjugation reactions of cresol isomers and the
relative amounts of glucuronide and sulfate conjugates therefore differ
between species and also vary with dose.
Reliability : (2) valid with restrictions
basic information
Flag : Critical study for SIDS endpoint
06.02.2004 (110) (112) (113) (114)
In Vitro/in vivo : In vivo
Type : Absorption
Species : rat
Number of animals
Males :
Females :
120
UNEP PUBLICATIONS