m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
5.1.1 ACUTE ORAL TOXICITY
Type : LD50
Value : = 1800 mg/kg bw
Species : rat
Strain : Wistar
Sex : male/female
Number of animals : 5
Vehicle : other: olive oil
Doses : 1300 - 2700 mg/kg bw
Method : other: 5 rats/sex/dose, administration as a 10% solution in olive oil to nonfasted
Wistar rats by gavage to give doses of 1000-2700 mg/kg bw,
observation time was not reported, section was not performed
Year : 1944
GLP : no data
Test substance : other TS: p-cresol, purity = 96-98%
Remark : Signs and symptoms of poisoning were similar to those caused
by phenol which included muscle twitching, temperature and
pulse and respiratory rate fluctuations, salivation and
uncoordinated leg movements. There was 100% mortality at
2700 mg/kg bw; time of death not mentioned
Result : Dose (mg/kg) Mortality (%)
1300 20
1500 40
1800 30
2000 50
2200 70
2400 90
2700 100
Reliability : (2) valid with restrictions
no guideline study: substance given as 10 % solution , description sufferes
from deficiencies (e.g.: observation time not reported)
Flag : Critical study for SIDS endpoint
06.02.2004 (136)
Type : LD50
Value : 775 - 1000 mg/kg bw
Species : mouse
Strain : ICR
Sex : male
Number of animals : 5
Vehicle : other: corn oil
Doses : 100 - 1000 mg/kg bw
Method : other: see freetext ME
Year : 1989
GLP : no data
Test substance : other TS: p-cresol, purity: 99.8%
Method : The test article was administered by oral gavage at a volume
of 5ml/kg. Pre-dosing weight of the animals was 28.0-34.8
grams. Dosing solutions were prepared just prior to dosing.
All animals were examined after dosing and periodically
throughout the seven day study for toxic effects and/or
mortalities.
Remark : Quality Assurance statement signed; Range-finding study for
mouse dominant lethal assay.
Result : 5 minutes of dosing, one animal at 775 mg/kg and one at 1000
mg/kg were exhibiting clonic convulsions and labored
breathing. All other animals were languid within 5 minutes
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