m-Cresol - ipcs inchem

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OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 5.1.1 ACUTE ORAL TOXICITY Type : LD50 Value : = 1800 mg/kg bw Species : rat Strain : Wistar Sex : male/female Number of animals : 5 Vehicle : other: olive oil Doses : 1300 - 2700 mg/kg bw Method : other: 5 rats/sex/dose, administration as a 10% solution in olive oil to nonfasted Wistar rats by gavage to give doses of 1000-2700 mg/kg bw, observation time was not reported, section was not performed Year : 1944 GLP : no data Test substance : other TS: p-cresol, purity = 96-98% Remark : Signs and symptoms of poisoning were similar to those caused by phenol which included muscle twitching, temperature and pulse and respiratory rate fluctuations, salivation and uncoordinated leg movements. There was 100% mortality at 2700 mg/kg bw; time of death not mentioned Result : Dose (mg/kg) Mortality (%) 1300 20 1500 40 1800 30 2000 50 2200 70 2400 90 2700 100 Reliability : (2) valid with restrictions no guideline study: substance given as 10 % solution , description sufferes from deficiencies (e.g.: observation time not reported) Flag : Critical study for SIDS endpoint 06.02.2004 (136) Type : LD50 Value : 775 - 1000 mg/kg bw Species : mouse Strain : ICR Sex : male Number of animals : 5 Vehicle : other: corn oil Doses : 100 - 1000 mg/kg bw Method : other: see freetext ME Year : 1989 GLP : no data Test substance : other TS: p-cresol, purity: 99.8% Method : The test article was administered by oral gavage at a volume of 5ml/kg. Pre-dosing weight of the animals was 28.0-34.8 grams. Dosing solutions were prepared just prior to dosing. All animals were examined after dosing and periodically throughout the seven day study for toxic effects and/or mortalities. Remark : Quality Assurance statement signed; Range-finding study for mouse dominant lethal assay. Result : 5 minutes of dosing, one animal at 775 mg/kg and one at 1000 mg/kg were exhibiting clonic convulsions and labored breathing. All other animals were languid within 5 minutes 254 UNEP PUBLICATIONS
OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 of dosing but resumed normal activity within 10 minutes. All surviving animals appeared normal and helthy on the eventh day after dosing. Summary of Mortalities: Treatment Observation 100 mg/kg 0/5 325 mg/kg 0/5 550 mg/kg 0/5 775 mg/kg 1/5 1000 mg/kg 3/5 Reliability : (2) valid with restrictions dose range finding study Flag : Critical study for SIDS endpoint 06.02.2004 (137) Type : LD50 Value : = 1460 mg/kg bw Species : rat Strain : Sex : Number of animals : Vehicle : Doses : Method : other Year : GLP : no data Test substance : other TS: purity not noted Remark : p-<strong>Cresol</strong> was administered as a 10% solution in oil. The original data are in Russian and no further experimental details are available from the citing review (IPCS, 1993). Reliability : (4) not assignable seondary literature 06.09.2002 (129) (138) Type : LD50 Value : = 344 mg/kg bw Species : mouse Strain : Sex : Number of animals : Vehicle : Doses : Method : other Year : 1976 GLP : no data Test substance : other TS: purity not noted Remark : p-<strong>Cresol</strong> was administered as a 10% solution in oil. The original data are in Russian and no further experimental details are available from the citing review (IPCS, 1993). Reliability : (4) not assignable secondary literature 06.01.2003 (129) (138) Type : LD0 Value : = 420 mg/kg bw Species : rabbit Strain : Sex : Number of animals : UNEP PUBLICATIONS 255
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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