m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Bray et al., Biochem J. 41, 212 (1947) and 43, 561 (1948)
Result : absorption and excretion:
Within 24 hours 84 % of the m-Cresol dose was excreted in the urine
indicating that at least this amount was absorbed through the
gastrointestinal tract and urinary excretion was the main route of
elimination.
metabolism:
The principal metabolic pathway was conjugation wit h glucuronic and
sulphuric acids: 10% of the dose were discovered as ethereal sulphate and
60% of the dose as etheral glucuronide and 1% of the dose as free cresol.
About 3 % of the dose was conjugated 2,5-dihydroxytoluene; conjugated
3,4-dihydroxytoluene was only discovered in traces.
Reliability : (2) valid with restrictions
no information on sex of rabbits used, no information on distribution in the
tissue
Flag : Critical study for SIDS endpoint
06.02.2004 (107) (108)
In Vitro/in vivo : In vitro
Type : Absorption
Species : other: human skin
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle : water
Route of administration : dermal
Exposure time : 250 minute(s)
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method :
Year :
GLP :
Test substance : other TS: m-cresol, not specified further
Method : The permeability of m-Cresol was measured across 2.5 cm2 epidermal
membranes from human abdominal skin. The membranes were supported
in a glass cell and the amount of m-Cresol passing to the receptor vessel
measured spectrophotometrically. Each test was conducted at least in
duplicate and at 25 Degree Celsius
Result : The permeability coefficient of m-Cresol was 2.54 x10 (exp)-4 cm/min and
the lag time for a 0.4%w/v solution was 15 min. The threshold
concentration for damage i.e. the aqueous concentration at which the
permeability coefficient began to increase was 1.0 %w/v.
Reliability : (2) valid with restrictions
in vitro investigation
Flag : Critical study for SIDS endpoint
06.02.2004 (109)
In Vitro/in vivo : In vivo
Type :
Species : other: dogs and rabbits
Number of animals
UNEP PUBLICATIONS 119