m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
(sternebrae, femur, or vertebrae, including marrow), brain, bronchi, clitoral
gland, epididymis, oesophagus, gallbladder, heart, kidney, large intestines
(caecum, colon, rectum), liver, lungs, lymph nodes (mesenteric), mammary
glands, nasal cavity and turbinates, oral cavity, ovaries, pancreas,
parathyroids, pharynx, pituirary, preputial gland, prostate, salivary glands,
scrotal sac, seminal vesicles, skin, small intestine (duodenum, ileum,
jejunum), spleen, stomach, testes, thymus, thyroid, tongue, trachea, tunica
vaginalis, urinary bladder, uterus and Zymbal's glands. Target organs and
gross lesions were examined at lower doses until a no-observed chemical
effect was determined. Target organs included the following: nasal
epithelium, bone marrow, liver, kidney and lymphoid organs. Organ weights
recorded for brain, liver, right kidney, thymus, heart, and lungs of all
animals, and the right testis of all males.
STATISTICAL METHODS:
nonparametric multiple comparison test of Dunn and Shirley,
Jonckheere's test
Remark :
mean compound consumption (mg/kg bw/day):
males females
0 ppm 0 0
300 ppm 50 60
1000 ppm 163 207
3000 ppm 469 564
10000 ppm 1410 1590
Consumption data for the top dose were not
calculated due to 100% mortality at this level.
Result : 30000 ppm: all mice died: 5 male and 5 female mice
10000 ppm: 1/5 male died, mean final body weights and mean body weight
gains for surviving males were significantly
lower than in the control groups; male and female: feed consumption was
depressed at the beginning of the study (individual animal data not given)
Clinical signs of toxicity
included hunched posture, rough hair coat, lethargy, and hypothermia in
the top-dose females that died and, together with laboured breathing and
paleness, in the males fed >/= 10000 ppm (individual animal data not
given)
At study termination weights (w) were sign. increased:
heart (male, rel. w at 10000 ppm, p