m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
systemic toxicity: NOAEL(male, female): 1000 ppm
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (150)
Type : Sub-chronic
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : gavage
Exposure period : 13 weeks
Frequency of treatm. : 7 days/week
Post exposure period : no
Doses : 0, 50, 175, 600 mg/kg bw/day dissolved in corn oil
Control group : yes, concurrent vehicle
NOAEL : 50 mg/kg bw
Method : other: see freetext ME
Year : 1986
GLP : yes
Test substance : other TS: p-cresol, purity: 99.9 %
Method : 30 rats/sex/dose,
additional 10 rats/sex/dose for baseline clinical pathology
interim kill at week 7
bws were recorded on test day1 and weekly thereafter; individual food
consumption data were collected weekly;
moribund/mortality check twice daily (moribund rats were killed and
necropsied); physical examination weekly; ophthalmologic examination
during quarantine period and in test week 13
HAEMATOLOGY
haemoglobin, haematocrit, prothrombine time (PT), erythrocyte count,
reticulocyte count, total and differential leucocyte count, activated partial
thromboplastin time (APTT)
CLINICAL CHEMISTRY
sodium, chloride, potassium. direct and total bilirubin, alkaline
phosphatase, total cholesterol, albumin, CO2, SGPT, SGOT, glucose,
BUN, globulin (calculated), total protein, creatinine, Albumin/Globulin ratio
(calculated
URINALYSIS
appearance, volume, colour, specific gravity, pH, protein, glucose, ketone,
bilirubin, urobilinogen, haemoglobin, microscopic examination
PATHOLOGY
determination of weights of:
heart, liver, spleen, brain, kidneys, gonads, adrenals, thyroid/parathyroid
examination of all control rats and high dose rats at study termination as
well as those that died during the study:
all gross lesions,
brain (3 levels), spleen, bone (with marrow), skeletal muscles, salivary
gland. mammary gland, thymus, thyroid (with parathyroid), lungs (with
mainstem bronchi), trachea, liver, urinary bladder, testes, prostate, ovaries,
corpus and cervix uteri, eye, pituitary gland, lymph node, spinal cord, heart,
aorta, siatic nerve, pancreas, oesophagus, kidneys, small and large
intestine, adrenals, stomach
STATISTICAL ANALYSIS
One-way Analysis of Variance tests with Dunnett's t-test
Result : 600 mg/kg: 3 females died within the first 3 days of dosing. Overt signs of
toxicity at this dose included lethargy, tremors, convulsions and coma.
BODY WEIGHT was sign. reduced (p