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Benders'dictionary of nutrition and food technology

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151dhool The name given to leaves <strong>of</strong> tea up to the stage <strong>of</strong> drying.DHSS US Department <strong>of</strong> Health <strong>and</strong> Human Services; web sitehttp://www.dhhs.gov/.dhupa See cocoa butter equivalents.diabetes Two distinct conditions: diabetes insipidus <strong>and</strong> diabetesmellitus. Diabetes insipidus is a metabolic disorder characterisedby extreme thirst, excessive consumption <strong>of</strong> liquids <strong>and</strong> urination,due to failure <strong>of</strong> secretion <strong>of</strong> the antidiuretic hormone.haemochromatosis is known as bronze diabetes.Diabetes mellitus is a metabolic disorder involving impairedmetabolism <strong>of</strong> glucose due either to failure <strong>of</strong> secretion <strong>of</strong>the hormone insulin (Type I, insulin-dependent diabetes) orimpaired responses <strong>of</strong> tissues to insulin (Type II, non-insulindependentdiabetes). If untreated, the blood concentration<strong>of</strong> glucose rises to abnormally high levels (hyperglycaemia)after a meal <strong>and</strong> glucose is excreted in the urine (glucosuria).Prolonged hyperglycaemia may damage nerves, blood vessels<strong>and</strong> kidneys, <strong>and</strong> lead to development <strong>of</strong> cataracts, so effectivecontrol <strong>of</strong> blood glucose levels is important.Type I diabetes develops in childhood (sometimes called juvenile-onsetdiabetes) <strong>and</strong> is due to failure to secrete insulin as aresult <strong>of</strong> progressive auto-immune destruction <strong>of</strong> pancreatic β-islet cells.Treatment is by injection <strong>of</strong> insulin, either purified frombeef or pig pancreas, now usually, biosynthetic human insulin,together with restriction <strong>of</strong> the intake <strong>of</strong> sugars.Type II diabetes generally arises in middle age (maturityonsetdiabetes) <strong>and</strong> is due to insulin resistance <strong>of</strong> tissues;secretion <strong>of</strong> insulin by the pancreas is higher than normal in theearly stages <strong>of</strong> the disease. It can sometimes be treated byrestricting the consumption <strong>of</strong> sugars <strong>and</strong> reducing weight, or bythe use <strong>of</strong> oral drugs which stimulate insulin secretion <strong>and</strong>/orenhance the insulin responsiveness <strong>of</strong> tissues (sulphonylureas<strong>and</strong> biguanides). It is also treated by injection <strong>of</strong> insulin tosupplement secretion from the pancreas <strong>and</strong> overcome theresistance.Impairment <strong>of</strong> glucose tolerance similar to that seen in diabetesmellitus sometimes occurs in late pregnancy, when it isknown as gestational diabetes. Sometimes pregnancy is the stressthat precipitates diabetes, <strong>and</strong> commonly the condition resolveswhen the child is born.Renal diabetes is the excretion <strong>of</strong> glucose in the urine withoutundue elevation <strong>of</strong> the blood glucose concentration. It is due toa reduction <strong>of</strong> the renal threshold, which allows the bloodglucose to be excreted.See also glucokinase; metabolic syndrome; mody.

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