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Benders'dictionary of nutrition and food technology

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306metaphysis Growing portion <strong>of</strong> a long bone, between the epiphysis<strong>and</strong> the shaft (diaphysis).metaproteins Products <strong>of</strong> the action <strong>of</strong> dilute acid or alkali onproteins; they are no longer soluble at their isoelectric points(see isoelectric focusing) but will dissolve in weak acid oralkali.metformin See hypoglycaemic agents.methaemoglobin Oxidised haemoglobin (unlike oxyhaemoglobinin which oxygen is reversibly bound without oxidising theiron); cannot transport oxygen. Present in small quantities innormal blood, increased after certain drugs <strong>and</strong> after smoking,<strong>and</strong> in babies after consumption <strong>of</strong> <strong>food</strong> or water containingmoderately high levels <strong>of</strong> nitrates. Rarely occurs as a geneticdisease, methaemoglobinaemia.methaglen (metheglin) A traditional British wine made fromhoney (<strong>and</strong> thus a form <strong>of</strong> mead) to which herbs are addedbefore fermentation. Originally for medicinal purposes.methanogens archaea found in rumen flora that producemethane (<strong>and</strong> hydrogen) as a metabolic end-product.methanol (methyl alcohol, wood alcohol) The first member <strong>of</strong> thealcohol series, chemically CH 3 —OH. It is a highly toxic substance<strong>and</strong> leads to mental disturbance, blindness <strong>and</strong> death when consumedover a period. See alcohol, denatured.methionine An essential amino acid, abbr Met (M), M r 149.2, pK a2.13, 9.28, codon AUG. One <strong>of</strong> the three containing sulphur.Cystine <strong>and</strong> cysteine (the other two sulphur amino acids) arenot essential, but can only be made from methionine, <strong>and</strong> thereforethe requirement for methionine is lower if there is an adequateintake <strong>of</strong> cyst(e)ine.Therefore the total sulphur amino acidcontent <strong>of</strong> <strong>food</strong>s is generally considered.methionine load test For vitamin b 6 status; measurement <strong>of</strong>urinary excretion <strong>of</strong> homocysteine after a test dose <strong>of</strong> 3g <strong>of</strong>methionine; the enzyme cystathionine synthetase (EC 4.2.1.22)is pyridoxal phosphate-dependent.methionine sulphoximine Formed by reaction between nitrogentrichloride (agene) <strong>and</strong> the amino acid methionine when flouris treated with agene as a bleaching agent. Causes running fits indogs, <strong>and</strong> although it has never been shown to be toxic to humanbeings, the use <strong>of</strong> agene as a flour improver was ab<strong>and</strong>oned inUK in 1955.Methocel TM Methyl cellulose.méthode champenoise Sparkling wine made by a secondfermentation in the bottle, as for champagne, but outside theChampagne region <strong>of</strong> north-eastern France.Meth<strong>of</strong>as TM Methyl hydroxypropyl cellulose.

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