Sorted By Test Name - Mayo Medical Laboratories

FIMM
91507
IGA
8157
urine protein electrophoresis. Abnormalities detected on serum protein electrophoresis (SPEP) should be
immunotyped to confirm and characterize the monoclonal protein. Immunotyping of monoclonal proteins
is usually done by immunofixation electrophoresis (IFE) and identifies the monoclonal immunoglobulin
heavy-chain (gamma, alpha, mu, delta, or epsilon) and/or light-chain type (kappa or lambda). It is
generally recommended that both SPEP and IFE be used as a screening panel. Because IFE is more
sensitive than SPEP, IFE is not only recommended as part of the initial screening process but also for
confirmation of complete response to therapy.
Useful For: Identification of monoclonal immunoglobulin heavy and light chains Documentation of
complete response to therapy
Interpretation: Immunofixation impression comments are made based on visual interpretation of gels.
Reference Values:
Negative (reported as positive or negative)
Clinical References: Kyle RA, Katzmann JA, Lust, JA, Dispenzieri A: Clinical indications and
applications of electrophoresis and immunofixation. In Manual of Clinical Laboratory Immunology. 6th
edition. Edited by NR Rose, RG Hamilton, B Detrick. Washington DC. ASM Press, 2002, pp 66-70
Immunofixation, CSF
Reference Values:
Reference Range: No monoclonal proteins added.
This test was developed and its performance characteristics
determined by Quest Diagnostics Nichols Institute. It has not been
cleared or approved by the U.S. Food and Drug Administration.
The FDA has determined that such clearance or approval is not
necessary. Performance characteristics refer to the analytical
performance of the test.
Test Performed By: Quest Diagnostics Nichols Institute
33608 Ortega Hwy
San Juan Capistrano, CA 92690-6130
Immunoglobulin A (IgA), Serum
Clinical Information: The gamma globulin band as seen in conventional serum protein
electrophoresis consists of 5 immunoglobulins. In normal serum, about 15% is immunoglobulin A (IgA).
Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum
protein electrophoresis. Monoclonal elevation of IgA characterize multiple myeloma. Decreased
immunoglobulin levels are found in patients with congenital deficiencies. For your convenience, we
recommend utilizing cascade testing for celiac disease. Cascade testing ensures that testing proceeds in an
algorithmic fashion. The following cascades are available; select the appropriate one for your specific
patient situation. Algorithms for the cascade tests are available in Special Instructions. -CDCOM/89201
Celiac Disease Comprehensive Cascade: complete testing including HLA DQ -CDSP/89199 Celiac
Disease Serology Cascade: complete testing excluding HLA DQ -CDGF/89200 Celiac Disease
Comprehensive Cascade for Patients on a Gluten-Free Diet: for patients already adhering to a gluten-free
diet To order individual tests, see Celiac Disease Diagnostic Testing Algorithm in Special Instructions.
Useful For: Detection or monitoring of monoclonal gammopathies and immune deficiencies
Interpretation: Increased serum immunoglobulin concentrations occur due to polyclonal or
oligoclonal immunoglobulin proliferation in hepatic disease (hepatitis, liver cirrhosis), connective tissue
diseases, acute and chronic infections, as well as in the cord blood of neonates with intrauterine and
perinatal infections. Elevation of immunoglobulin A may occur in monoclonal gammopathies such as
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