Sorted By Test Name - Mayo Medical Laboratories

FRTLP
89040
89041
Clinical References: 1. World Heath Organization Classification of Tumours. Pathology and
Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Edited by ES Jaffe, NL Harris, H Stein,
JW Vardiman. Lyon, IARC Press, 2001 2. Gesk S, Martin-Subero JI, Harder L, et al: Molecular
cytogenetic detection of chromosomal breakpoints in T-cell receptor gene loci. Leukemia
2003;17:738-745 3. Chin M, Mugishima H, Takamura M, et al: Hemophagocytic syndrome and
hepatosplenic (gamma)(delta) T-cell lymphoma with isochromosome 7q and 8 trisomy. J Pediatr Hematol
Oncol 2004;26(6):375-378 4. Graux C, Cools J, Michaux L, et al: Cytogenetics and molecular genetics of
T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 2006;20:1496-1510 5.
Cayuela JM, Madani A, Sanhes L, et al: Multiple tumor-suppressor gene 1 inactivation is the most
frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood 1996;87:2180-2186 6. Hayette
S, Tigaud I, Maguer-Satta V, et al: Recurrent involvement of the MLL gene in adult T-lineage acute
lymphoblastic leukemia. Blood 2002;99:4647-4649 7. Graux C, Cools J, Melotte C, et al: Fusion of
NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet
2004;36:1084-1089
T-Cell Lymphoma, FISH, Blood or Bone Marrow
Clinical Information: T-cell neoplasms are relatively uncommon, accounting for approximately 12%
of all non-Hodgkin lymphomas. There are several subtypes of T-cell neoplasms: T-cell acute
lymphoblastic leukemia (T-ALL), T-cell prolymphocytic leukemia (T-PLL), T-cell large granular
lymphocytic leukemia (T-LGL), anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma,
and various other cutaneous, nodal, and extranodal lymphoma subtypes. The 2 most prevalent lymphoma
subtypes are unspecified peripheral T-cell lymphoma (3.7%) and ALCL (2.4%). T-cell neoplasms are
among the most aggressive of all hematologic and lymphoid neoplasms with the exception of ALCL,
which is usually responsive to chemotherapy. There are a few common chromosome anomalies associated
with specific subtypes, which this FISH test can detect: -inv(14)(q11q32) and t(14;14)(q11;q32), which
involve the T-cell leukemia/lymphoma 1 gene (TCL1A) and have been associated with T-PLL
-Isochromosome 7q and trisomy 8, which have been associated with hepatosplenic T-cell lymphoma
These probes have diagnostic relevance and can also be used to track response to therapy. This assay
detects chromosome abnormalities observed in the blood and bone marrow of patients with T-cell
lymphoma (for patients with T-cell acute leukemia, see FRTAL/88783 T-Cell Acute Lymphoblastic
Leukemia [T-ALL], FISH).
Useful For: Detecting a neoplastic clone associated with the common chromosome anomalies seen in
patients with various T-cell lymphomas Tracking known chromosome anomalies and response to therapy
in patients with T-cell lymphoma
Interpretation: A neoplastic clone is detected when the percent of cells with an abnormality exceeds
the normal reference range for any given probe. Detection of an abnormal clone supports a diagnosis of a
T-cell lymphoma. The specific anomaly detected may help subtype the neoplasm. The absence of an
abnormal clone does not rule out the presence of neoplastic disorder.
Reference Values:
An interpretive report will be provided.
Clinical References: 1. World Heath Organization Classification of Tumours. Pathology and
Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Edited by ES Jaffe, NL Harris, H Stein,
JW Vardiman. Lyon, IARC Press, 2001 2. Gesk S, Martin-Subero JI, Harder L, et al: Molecular
cytogenetic detection of chromosomal breakpoints in T-cell receptor gene loci. Leukemia
2003;17:738-745 3. Chin M, Mugishima H, Takamura M, et al: Hemophagocytic syndrome and
hepatosplenic (gamma)(delta) T-cell lymphoma with isochromosome 7q and 8 trisomy. J Pediatr Hematol
Oncol 2004;26(6):375-378
T-Cell Lymphoma, FISH, Tissue
Clinical Information: T-cell malignancies account for approximately 12% of all non-Hodgkin
lymphomas. There are several subtypes of T-cell neoplasms: T-cell acute lymphoblastic leukemia
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1682