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Sorted By Test Name - Mayo Medical Laboratories

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FPHAB<br />

57371<br />

FPHOS<br />

57310<br />

ACLIP<br />

86179<br />

3 3.50-17.4 Positive<br />

4 17.5-49.9 Strongly positive<br />

5 50.0-99.9 Strongly positive<br />

6 > or =100 Strongly positive Reference values<br />

apply to all ages.<br />

Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by<br />

Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,<br />

Chapter 53, Part VI, pp. 961-971, 2007<br />

Phosphatidylinositol Antibodies, IgG, IgM and IgA<br />

Reference Values:<br />

Phosphatidylinositol Antibody IgG (0 – 18) U/mL<br />

Phosphatidylinositol Antibody IgM (0 – 18) U/mL<br />

Phosphatidylinositol Antibody IgA (0 – 18) U/mL<br />

0 – 11 u/mL: Normal<br />

12 – 18 u/mL: Equivocal. Suggest repeat testing in 4 – 6 weeks or consider antibody<br />

testing for cardiolipin IgG and IgM, beta-2 glycoprotein 1 IgG and IgM and lupus anticoagulant.<br />

19 or greater u/mL: Positive<br />

<strong>Test</strong> Performed by: ARUP <strong>Laboratories</strong><br />

500 Chipeta Way<br />

Salt Lake City, UT 84108<br />

Phosphatidylserine Antibodies, IgG, IgM, IgA<br />

Reference Values:<br />

Phosphatidylserine Antibody IgG (0-10) U/mL<br />

Phosphatidylserine Antibody IgM (0-24) U/mL<br />

Phosphatidylserine Antibody IgA (0-19) U/mL<br />

<strong>Test</strong> Performed by: ARUP <strong>Laboratories</strong><br />

500 Chipeta Way<br />

Salt Lake City, UT 84108<br />

Phospholipid (Cardiolipin) Antibodies, IgA, Serum<br />

Clinical Information: The plasma membranes of mammalian cells are formed from phospholipids.<br />

Anionic phospholipids (eg, phosphatidylserine) are found on the cytoplasmic surface and neutral<br />

phospholipids (eg, phosphatidylcholine) predominate on the external surface. Membrane phospholipids<br />

participate in several important cellular functions including exchanging metabolites across membranes,<br />

transferring molecular signals and serving as a platform for the assembly of protein-lipid complexes.(1)<br />

Cellular activation is often accompanied by the translocation of anionic phospholipids to the external<br />

membrane surface. For example, during platelet-mediated blood coagulation, phosphatidylserine is<br />

translocated from the inner platelet membrane and provides a surface for the assembly of the<br />

prothrombinase enzyme complex that catalyzes the formation of thrombin. Complexes of negatively<br />

charged (anionic) phospholipids and endogenous plasma proteins provide epitopes recognized by natural<br />

autoantibodies.(2) Plasma from normal individuals contains low concentrations of natural IgG<br />

autoantibodies of moderate affinity. Pathologic levels of autoantibodies reflect loss of tolerance and<br />

increased production of antibodies. These autoantibodies are called phospholipid or cardiolipin antibodies<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 1404

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