Sorted By Test Name - Mayo Medical Laboratories

concentrations of IgG antibodies to Streptococcus pneumoniae serotypes often show at least a 2-fold
increase (paired sera). The number of different serotypes to which healthy adults respond is variable. The
minimum serologic response necessary to identify an individual as "normal" has not been defined, either
for the number of serotypes or the magnitude of response in units of concentration. Serotype-specific
antibodies may persist for up to 10 years following immunization or infection.
Reference Values:
Serotype Normal Value
1 (1) >8.2
2 (2) >7.4
3 (3) >6.9
4 (4) >4.1
5 (5) >28.8
8 (8) >13.3
9N (9) >16.6
12F (12) >4.3
14 (14) >22.9
17F (17) >44.8
19F (19) >16.0
20 (20) >12.1
22F (22) >32.4
23F (23) >49.0
6B (26) >15.3
10A (34) >25.5
11A (43) >9.7
7F (51) >30.8
15B (54) >12.8
18C (56) >7.0
19A (57) >28.1
9V (68) >44.0
33F (70) >7.5
Clinical References: 1. Schuchat A, Robinson K, Wenger JD, et al: Bacterial meningitis in the
United States in 1995. Active surveillance team. N Engl J Med 1997 October;337(14):970-976 2.
Zangwill KM, Vadheim CM, Vannier AM, et al: Epidemiology of invasive pneumococcal disease in
southern California: implications for the design and conduct of a pneumococcal conjugate vaccine
efficacy trial. J Infect Dis 1996 October;174(4):752-759 3. Butler JC, Breiman RF, Lipman HB, et al:
Serotype distribution of Streptococcus pneumoniae infections among preschool children in the United
States, 1978-1994: implications for development of a conjugate vaccine. J Infect Dis 1995
April;171(4):885-889 4. Butler JC, Hoffman J, Cetron MS, et al: The continued emergence of
drug-resistant Streptococcus pneumoniae in the United States: an update from the Centers for Disease
Control and Prevention's Pneumococcal Sentinel Surveillance System. J Infect Dis 1996
November;174(5):986-993 5. Jacob GL, Homburger HA: Simultaneous Quantitative Measurement of IgG
Antibodies to Streptococcus Pneumoniae Serotypes by Microsphere Photometry. J Allergy Clin
Immunol,2004;113(2) Suppl (Abstract 1049, pS288) 6. Plikaytis BD, Holder PF, Pais LB, et al:
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