Sorted By Test Name - Mayo Medical Laboratories

DTHC
505331
and kidney. Toxic manifestations are similar to those produced by codeine and include respiratory and
CNS depression, cardiac arrhythmias, pulmonary edema, hypotension, hallucinations, convulsions, and
coma. Accidental or intentional ingestion of large amounts of propoxyphene may cause death.
Useful For: Detecting and confirming drug abuse involving propoxyphene
Interpretation: A positive result derived by this testing indicates that the patient has used
propoxyphene in the recent past. Random urine collection results are not clinically definitive but the
following values may be used as guidelines: Propoxyphene: 1,000-5,000 ng/mL; typical for therapeutic
dosages >10,000 ng/mL; may indicate toxic blood concentration >80,000 ng/mL; may indicate potentially
lethal blood concentration Norpropoxyphene: 2,000-20,000 ng/mL; typical for therapeutic dosages
>30,000 ng/mL; may indicate toxic blood concentration >80,000 ng/mL; may indicate potentially lethal
blood concentration
Reference Values:
EMIT cutoff concentration: 300 ng/mL
Positives are reported with a quantitative GC-MS result.
GC/MS cutoff concentrations
Propoxyphene: 15
ng/mL is a strong indicator that the patient has used marijuana. The presence of THC-COOH in urine at
concentrations >100 ng/mL indicates relatively recent use, probably within the past 7 days. Levels >500
ng/mL suggest chronic and recent use. Chronic use causes accumulation of the THC and THC-COOH in
adipose tissue such that it is excreted into the urine for as long as 30 to 60 days from the time chronic use
is halted.
Reference Values:
Negative
EMIT cutoff concentration: 50 ng/mL
Positives are reported with a quantitative GC/MS result.
Clinical References: 1. Moyer TP, Palmen MA, Johnson P, et al: Marijuana testing-how good is it?
Mayo Clin Proc 1987;62:413-417 2. Baselt RC, Cravey RH: Disposition of Toxic Drugs and Chemicals in
Man. 3rd edition. Chicago, Year Book Medical Publishers, 1989
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