Sorted By Test Name - Mayo Medical Laboratories

LPSBF
83690
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat
proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,
2007 Chapter 53, Part VI, pp 961-971
Lipase, Body Fluid
Clinical Information: Lipases are enzymes that hydrolyze glycerol esters of long-chain fatty acids
and produce fatty acids and 1-acylglycerol. Bile salts and a cofactor, colipase, are required for full
catalytic activity and greatest specificity. The pancreas is the primary source of serum lipase. Both lipase
and colipase are synthesized in the pancreatic acinar cells and secreted by the pancreas in roughly
equimolar amounts. Serum lipase is filtered and reabsorbed by the kidneys. Pancreatic injury results in
increased serum lipase levels. In pancreatitis, serum lipase becomes elevated at about the same time as
serum amylase (in 4-8 hours). But serum lipase may rise to a greater extent and remain elevated much
longer (7-10 days) than serum amylase. Elevations in serum lipase up to 50 times the upper reference
values have been reported. The increase in serum lipase is not necessarily proportional to the severity of
the attack and normalization is not necessarily a sign of resolution. Both lipase and amylase should be
very elevated in peritoneal fluid arising from the pancreas. Values in fluid of pancreatic origin should be
at least several-fold higher than serum drawn at the same time, even in acute pancreatitis.
Useful For: Investigating pancreatic disorders, usually pancreatitis or pancreatic pseudocysts
Interpretation: Very high values are consistent with pancreatic pseudocysts.
Reference Values:
Not applicable
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