Sorted By Test Name - Mayo Medical Laboratories

FPGD2
90154
FPGE2
90167
Prostaglandin D2 (PGD2), Serum or Plasma
Clinical Information: Prostaglandins are fatty acids derived from arachidonic acid metabolism. They
are closely related to the Thromboxanes and Leukotrienes. Prostaglandin D2 is derived mainly from
Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin D2. Prostaglandin D2 is excreted
directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines,
and stomach. Prostaglandin D2 is the major Prostaglandin produced by uterine tissue. Prostaglandin D2 is
a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent. It also stimulates the secretion
of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti-metastatic effect on many
malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by
aspirin and Indomethacin.
Reference Values:
35-115 pg/mL
No pediatric reference ranges available for this test.
This test was performed using a kit that has not been cleared or approved by the FDA and is designated
as research use only. The analytic performance characteristics of this test have been determined by Inter
Science Institute. This test is not intended for diagnosis or patient management decisions without
confirmation by other medically established means.
Test Performed By: Interscience Institute
944 West Hyde Park Blvd
Inglewood, CA 90302
Prostaglandin E2 (PG E2), Urine
Clinical Information: Prostaglandins are fatty acids derived from arachidonic acid metabolism. They
are closely related to the Thromboxanes and Leukotrienes. Prostaglandin E2 is derived mainly from
Prostaglandin H2, and is metabolized to Prostaglandin F2a, A2, and Dihydroketo Prostaglandin E2.
Prostaglandin E2 is excreted directly into the urine. Prostaglandin E2 is a potent vasodilator and also a
stimulus for Renin release. Prostaglandin E2 release is stimulated by cholinergic and alpha adrenergic
agents. Prostaglandin E2 potentiates the actions of Histamine and Bradykinin causing pain and
accumulation of edema fluid. It relaxes the circular muscle of the gut in opposition to ProstaglandinF2a,
and also relaxes the lower esophageal sphincter. Prostaglandin E2 also causes accumulation of water and
electrolytes in the lumen of the gut by stimulating their secretion. Elevated levels of Prostaglandin E2
have been detected in patients with the Watery Diarrhea Syndrome, neural crest tumors,
pheochromocytomas, and other amine-peptide-secreting tumors. Prostaglandin E2 production and
circulating levels are drastically suppressed by aspirin and indomethacin. Urine Prostaglandin E2 levels
give an integrated picture of Prostaglandin E2 production over a 24 hour minimizing the effect of diurnal
variation and episodic secretion.
Reference Values:
400-620 ng/24 hours
This test was performed using a kit that has not been cleared or approved by the FDA and is designated
as research use only. The analytic performance characteristics of this test have been determined by Inter
Science Institute. This test is not intended for diagnosis or patient management decisions without
confirmation by other medically established means.
Test Performed by: Inter Science Institute
944 West Hyde Park Blvd.
Inglewood, CA 90302
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1485